Automated Organization ProfileInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets in this organization
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the organization's datasets
Total Mentions
Total mentions of the organization's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 1.8 (sum of 2 datasets Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity.
Authors
- Barradas, Marta ;
- Plaza, Adrian ;
- Colmenarejo, Gonzalo ;
- Lázaro, Iolanda ;
- Costa-Machado, Luis Filipe ;
- Martín-Hernández, Roberto ;
- Micó, Victor ;
- López-Aceituno, José Luis ;
- Herranz, Jesús ;
- Pantoja, Cristina ;
- Tejero, Hector ;
- Diaz-Ruiz, Alberto ;
- Al-Shahrour, Fatima ;
- Daimiel, Lidia ;
- Loria-Kohen, Viviana ;
- Ramirez de Molina, Ana ;
- Efeyan, Alejo ;
- Serrano, Manuel ;
- Pozo, Oscar J. ;
- Sala-Vila, Aleix ;
- Fernandez-Marcos, Pablo J.
Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity.
Authors
- Barradas, Marta ;
- Plaza, Adrian ;
- Colmenarejo, Gonzalo ;
- Lázaro, Iolanda ;
- Costa-Machado, Luis Filipe ;
- Martín-Hernández, Roberto ;
- Micó, Victor ;
- López-Aceituno, José Luis ;
- Herranz, Jesús ;
- Pantoja, Cristina ;
- Tejero, Hector ;
- Diaz-Ruiz, Alberto ;
- Al-Shahrour, Fatima ;
- Daimiel, Lidia ;
- Loria-Kohen, Viviana ;
- Ramirez de Molina, Ana ;
- Efeyan, Alejo ;
- Serrano, Manuel ;
- Pozo, Oscar J. ;
- Sala-Vila, Aleix ;
- Fernandez-Marcos, Pablo J.