The national Fire and Fire Surrogate (FFS) study was initiated more than two decades ago with the goal of evaluating the ecological impacts of mechanical treatments and prescribed fire in different ecosystems across the United States. Since then, 4 of the original 12 sites remain active in managing and monitoring the original FFS study which provides a unique opportunity to look at the long-term effects of these treatments in different regions. These sites include California (Blodgett Forest Research Station), Montana (Lubrecht Experimental Forest), North Carolina (Green River Game Land) and Ohio (Ohio Hills). Although regions differed in ecosystem type (e.g., conifer- vs. hardwood-dominated), the overall goals of the FFS study were to promote desirable, fire-adapted species, reduce fire hazard, and improve understory diversity. Our study uses multivariate techniques to compare how these desired outcomes were maintained over the last 20 years and discusses whether we would modify the original treatments given what we know now. Our findings indicate that mechanical treatments and prescribed fire can promote desired tree species, mitigate potential fire behavior by reducing fuels and retaining larger-sized trees, decrease tree mortality, and stimulate regeneration – effects that are still apparent even after 20 years. However, we also found that maintaining desired outcomes was regionally specific with western sites (California and Montana) showing more desirable characteristics under mechanical treatments, while the eastern sites (North Carolina and Ohio) showed more desirable characteristics after prescribed burning. The beneficial effects of treatment were also more apparent in the long term when sites followed up with repeated treatments, which can be adapted to meet new objectives and conditions. These findings highlight the FFS study as an invaluable resource for research and provide evidence for meeting long-term restoration goals if treatments can be adapted to ecosystem type, be maintained by repeated treatments, and can accommodate new goals by adapting treatments to changing conditions.