One of the grand quests in neuroscience is to build complete maps of the brain, charting all of its cells and the connections between them. Such wiring diagrams, called connectomes, promise to shed light on how networks of neurons can give rise to thoughts, memories, and actions, and to help reveal the underlying causes of neurological diseases. However, due to the scale of mammalian brains new technologies are needed to comprehensively map them.In our previous LTP (LS2892, 2021-2023), we established X-ray coherent microscopy as a new technique for mapping of large tissue samples. We propose extending our LTP to use the techniques we recently developed to map several brain regions with unprecedented detail, including the neocortex, cerebellum, and hypothalamus. These datasets will reveal fundamental organizational principles of brain networks, and further establish X-ray microscopy as a critical technique for global efforts to completely map mammalian brains.

No description available

This is the dataset for the following manuscript: Do ESG Frameworks Capture Corporate Health Impacts? An Analysis of the Food and Beverage Industry (published in TBD).The first file (Mapped metrics) shows the metrics that we extracted from the ESG frameworks and mapped to the HEALTH-CORP-FB typology. The metrics from the Bloomberg and S&P Global ESG Rating systems are excluded as this data is proprietary and we are not able to share it publicly. The metrics for the GRI Standards, SASB Standards, and JUST Capital Rankings can be accessed publicly at the websites of the respective organizations. The file contains information on the document version dates that we used in this study. The second file (Coded metrics) displays the classifications that we assigned to each mapped metric for the attributes of relevance and type of business operations. For industry-specific frameworks, only metrics mapped to the HEALTH-CORP-FB typology from the "processed food" sub-industry were coded. Specifically, we classified the fields in the SASB Processed Foods industry, the Bloomberg Packaged Food subindustry, and the S&P Global Food Products subindustry. For non-industry specific frameworks, we classified all of the mapped fields (i.e., GRI, JUST Capital). The file contains information on the document version dates that we used in this study. See the ReadMe tab in each file for additional information. For any other questions or clarifications, please contact Raquel Burgess at [email protected].

A database of inflected word tokens in Blackfoot (Algonquian; ISO-639-3: bla). Each word token is analyzed into its constituent stem and morpheme tokens, including their containment relationships. Each stem and morpheme token is linked to an abstract lemma type. For more information, see https://www.blackfootwords.com/.

The <a href="https://tischcollege.tufts.edu/research-faculty/research-centers/cooperative-election-study">Cooperative Election Study</a> (CES), previously called the Cooperative Congressional Election Study (CCES), is one of the largest political surveys in the United States.This cumulative dataset contains the respondents from the Common Content of the CCES (n = 701,955), combining all available Common Content datasets from 2006 - 2024. It includes select standardized variables including demographics, geography, vote choice, validated vote, representative approval, and views on the economy. See the attached guide for a full list of variables, methodology, and ways to load the data. V11 includes vote validation variables from 2024, and several other changes noted at the end of the Guide.

Calcium (Ca²⁺) release from intracellular stores, Ca²⁺ entry across the plasma membrane, and their coordination via store-operated Ca²⁺ entry (SOCE) are critical for receptor-activated Ca²⁺ oscillations. However, the precise mechanism of Ca²⁺ oscillations and whether their control loop resides at the plasma membrane or intracellularly remain unresolved. By examining the dynamics of stromal interaction molecule 1 (STIM1), an endoplasmic reticulum (ER)-localized Ca²⁺ sensor that activates the Orai1 channel on the plasma membrane for SOCE, in mast cells, we found that a significant proportion of cells exhibited STIM1 oscillations with the same periodicity as Ca²⁺ oscillations. These cortical oscillations, shared with ER-plasma membrane (ER-PM) contact sites proteins, were only detectable using total internal reflection fluorescence microscopy (TIRFM). Notably, STIM1 oscillations could occur independently of Ca²⁺ oscillations. Simultaneous imaging of cytoplasmic Ca²⁺ and ER Ca²⁺ with CEPIA1er revealed that receptor activation does not deplete ER Ca²⁺, whereas receptor activation without extracellular Ca²⁺ influx induces cyclic ER Ca²⁺ depletion. However, under such nonphysiological conditions, cyclic ER Ca²⁺ oscillations lead to sustained STIM1 recruitment, indicating that oscillatory Ca²⁺ release is neither necessary nor sufficient for STIM1 oscillations. Using optogenetic tools to manipulate ER-PM contact site dynamics, we found that persistent ER-PM contact sites reduced the amplitude of Ca²⁺ oscillations without alteration of oscillation frequency. Together, these findings suggest an active cortical mechanism governs the rapid dissociation of ER-PM contact sites, thereby control amplitude of oscillatory Ca²⁺ dynamics during receptor-induced Ca²⁺ oscillations.

Calcium (Ca²⁺) release from intracellular stores, Ca²⁺ entry across the plasma membrane, and their coordination via store-operated Ca²⁺ entry (SOCE) are critical for receptor-activated Ca²⁺ oscillations. However, the precise mechanism of Ca²⁺ oscillations and whether their control loop resides at the plasma membrane or intracellularly remain unresolved. By examining the dynamics of stromal interaction molecule 1 (STIM1), an endoplasmic reticulum (ER)-localized Ca²⁺ sensor that activates the Orai1 channel on the plasma membrane for SOCE, in mast cells, we found that a significant proportion of cells exhibited STIM1 oscillations with the same periodicity as Ca²⁺ oscillations. These cortical oscillations, shared with ER-plasma membrane (ER-PM) contact sites proteins, were only detectable using total internal reflection fluorescence microscopy (TIRFM). Notably, STIM1 oscillations could occur independently of Ca²⁺ oscillations. Simultaneous imaging of cytoplasmic Ca²⁺ and ER Ca²⁺ with CEPIA1er revealed that receptor activation does not deplete ER Ca²⁺, whereas receptor activation without extracellular Ca²⁺ influx induces cyclic ER Ca²⁺ depletion. However, under such nonphysiological conditions, cyclic ER Ca²⁺ oscillations lead to sustained STIM1 recruitment, indicating that oscillatory Ca²⁺ release is neither necessary nor sufficient for STIM1 oscillations. Using optogenetic tools to manipulate ER-PM contact site dynamics, we found that persistent ER-PM contact sites reduced the amplitude of Ca²⁺ oscillations without alteration of oscillation frequency. Together, these findings suggest an active cortical mechanism governs the rapid dissociation of ER-PM contact sites, thereby control amplitude of oscillatory Ca²⁺ dynamics during receptor-induced Ca²⁺ oscillations.

This repository contains the dataset and R scripts used to perform all analyses for the study “How Thermal Tolerance Shapes Species Distributions: An Integrative Perspective on the Most Diverse Lizard Family in North America.” by Laura R. V. Alencar, Kiran Masroor, Saúl F. Domínguez-Guerrero, Julia Laterza-Barbosa, Meaghan R. Gade, Josef C. Uyeda, and Martha M. Muñoz.

This repository contains the dataset and R scripts used to perform all analyses for the study “How Thermal Tolerance Shapes Species Distributions: An Integrative Perspective on the Most Diverse Lizard Family in North America.” by Laura R. V. Alencar, Kiran Masroor, Saúl F. Domínguez-Guerrero, Julia Laterza-Barbosa, Meaghan R. Gade, Josef C. Uyeda, and Martha M. Muñoz.

This is a citable version of the online Enhanced Weathering (EW) bibliography spreadsheet. Both the spreadsheet as well as the version here are updated ~once a month to reflect new publications.The spreadsheet can also be found here: https://tinyurl.com/ERWlitAnd missing entries can be submitted here: https://tinyurl.com/ERWmorelitPlease note that the file has multiple sheets; in addition to studies on EW they contain studies that have used rock flour as a fertilizer, studies on coastal and ocean EW, EW of mine tailings / waste streams in non-agricultural settings, as well as EW using reactor designs. Please note that only the first spreadsheed (terrestrial, agricultural EW) is maintained regurlarly and likely rather complete due to a systematic screening process. The bibliography for other areas of EW is likely less complete.