Supplementary dataset 1 This file contains datasets for all 230 overlapped DEGs (Fig. 6A and B) among RTM, MTM, and control group compared with the PCOS group in F0 model mice. It has two sheets: "F0 up-regulated DEGs" contained all DEGs that have significantly higher (|log2| > 1) expression levels in RTM, MTM, and control group than PCOS group; "F0 down-regulated DEGs" contained all DEGs that have significantly lower (|log2| > 1) expression level in RTM, MTM, and control group than PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown. Supplementary dataset 2 This file, corresponding to Fig. 7, contains 4 sheets of datasets for all DEGs that overlapped between human PCOS studies and corrent study. From left to right, in sheet 1, the datasets from column A-AB are for the DEGs in current study; the datasets from column AD-BL are for the DEGs in Lan et al (36). In sheet 2, the datasets from column A-AA are for the DEGs in our study; the datasets from column AC-AI are for the DEGs in Wissing et al (37). In sheet 3, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AL are for the DEGs in Lu et al (38). In sheet 4, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AG are for the DEGs in Kaur et al (39). For a clear distinguishment between our data and the reference data, column AC in sheet 1, column AB in sheet 2, column AC in sheet 3, and column AC in sheet 4 are left blank and highlighted in green; Two columns with title "symbol" and red typed in each sheet list all overlapping DEGs between our data and reference data. Supplementary dataset 3 This file contains 4 sheets. Each sheet includes KEGG information for the DEGs that overlapped between human PCOS studies and current study. Supplementary dataset 4 This dataset contains all 126 overlapped DEGs (Supplementary Fig. 6A and B) among RTM, MTM, and control group compared with the PCOS group in F1 model mice. It has two sheets: "F1 up-regulated DEGs" contained all DEGs that have significantly higher (|log2| > 1) expression level in RTM, MTM, and control group than in PCOS group; "F1 down-regulated DEGs" contained all DEGs that have significantly lower (|log2| > 1) expression level in RTM, MTM, and control group than in PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown.

Supplementary dataset 1 This file contains datasets for all 230 overlapped DEGs (Fig. 6A and B) among RTM, MTM, and control group compared with the PCOS group in F0 model mice. It has two sheets: "F0 up-regulated DEGs" contained all DEGs that have significantly higher (|log2| > 1) expression levels in RTM, MTM, and control group than PCOS group; "F0 down-regulated DEGs" contained all DEGs that have significantly lower (|log2| > 1) expression level in RTM, MTM, and control group than PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown. Supplementary dataset 2 This file, corresponding to Fig. 7, contains 4 sheets of datasets for all DEGs that overlapped between human PCOS studies and corrent study. From left to right, in sheet 1, the datasets from column A-AB are for the DEGs in current study; the datasets from column AD-BL are for the DEGs in Lan et al (36). In sheet 2, the datasets from column A-AA are for the DEGs in our study; the datasets from column AC-AI are for the DEGs in Wissing et al (37). In sheet 3, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AL are for the DEGs in Lu et al (38). In sheet 4, the datasets from column A-AB are for the DEGs in our study; the datasets from column AD-AG are for the DEGs in Kaur et al (39). For a clear distinguishment between our data and the reference data, column AC in sheet 1, column AB in sheet 2, column AC in sheet 3, and column AC in sheet 4 are left blank and highlighted in green; Two columns with title "symbol" and red typed in each sheet list all overlapping DEGs between our data and reference data. Supplementary dataset 3 This file contains 4 sheets. Each sheet includes KEGG information for the DEGs that overlapped between human PCOS studies and current study. Supplementary dataset 4 This dataset contains all 126 overlapped DEGs (Supplementary Fig. 6A and B) among RTM, MTM, and control group compared with the PCOS group in F1 model mice. It has two sheets: "F1 up-regulated DEGs" contained all DEGs that have significantly higher (|log2| > 1) expression level in RTM, MTM, and control group than in PCOS group; "F1 down-regulated DEGs" contained all DEGs that have significantly lower (|log2| > 1) expression level in RTM, MTM, and control group than in PCOS group. For each gene, both FPKM of each repeat and the average FPKM of three repeats are shown.