Automated Author ProfileShields, Mallory
Shields, Mallory
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 61.1 (sum of 33 datasets Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
Following nerve stimulation, there are two distinct phases of Ca2+-dependent neurotransmitter release: a fast, synchronous release phase, and a prolonged, asynchronous release phase. Each of these phases is tightly regulated and mediated by distinct mechanisms. Synaptotagmin 1 is the major Ca2+ sensor that triggers fast, synchronous neurotransmitter release upon Ca2+ binding by its C2A and C2B domains. It has also been implicated in the inhibition of asynchronous neurotransmitter release, as blocking Ca2+ binding by the C2A domain of synaptotagmin 1 results in increased asynchronous release. However, the mutation used to block Ca2+ binding in the previous experiments (aspartate to asparagine mutations, sytD-N) had the unintended side effect of mimicking Ca2+ binding, raising the possibility that the increase in asynchronous release was directly caused by ostensibly constitutive Ca2+ binding. Thus, rather than modulating an asynchronous sensor, sytD-N may be mimicking one. To directly test this C2A inhibition hypothesis, we utilized an alternate C2A mutation that we designed to block Ca2+ binding without mimicking it (an aspartate to glutamate mutation, sytD-E). Analysis of both the original sytD-N mutation and our alternate sytD-E mutation at the Drosophila neuromuscular junction showed differential effects on asynchronous release, as well as on synchronous release and the frequency of spontaneous release. Importantly, we found that asynchronous release is not increased in the sytD-E mutant. Thus, our work provides new mechanistic insight into synaptotagmin 1 function during Ca2+-evoked synaptic transmission and demonstrates that Ca2+ binding by the C2A domain of synaptotagmin 1 does not inhibit asynchronous neurotransmitter release in vivo.
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Kramer, Hannah ;
- Fulcer, McKenzie ;
- Perinet, Lara ;
- Metz, Marissa ;
- Reist, Noreen
No description available
Authors
- Bowers, Matthew ;
- Shields, Mallory ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen
No description available
Authors
- Shields, Mallory ;
- Bowers, Matthew ;
- Fulcer, McKenzie ;
- Bollig, Madelyn ;
- Rock, Patrick ;
- Sutton, Roger ;
- Vrailas-Mortimer, Alysia ;
- Lochmüller, Hanns ;
- Whittaker, Roger ;
- Horvath, Rita ;
- Reist, Noreen