Automated Author ProfileWebb, Shaun
Webb, Shaun
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 7.4 (sum of 7 datasets Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
Patterns of gene expression are primarily determined by proteins that locally enhance or repress transcription. While many transcription factors target a restricted number of genes, others appear to modulate transcription levels globally. An example is MeCP2, an abundant methylated-DNA binding protein that is mutated in the neurological disorder Rett Syndrome. Despite much research, the molecular mechanism by which MeCP2 regulates gene expression is not fully resolved. Here we integrate quantitative, multi-dimensional experimental analysis and mathematical modelling to show that MeCP2 is a novel type of global transcriptional regulator whose binding to DNA creates "slow sites" in gene bodies. Waves of slowed-down RNA polymerase II formed behind these sites travel backward and indirectly affect initiation, reminiscent of defect-induced shock waves in non-equilibrium physics transport models. This mechanism differs from conventional gene regulation mechanisms, which often involve direct modulation of transcription initiation. Our findings point to a genome-wide function of DNA methylation that may account for the reversibility of Rett syndrome in mice. Moreover, our combined theoretical and experimental approach provides a general method for understanding how global gene expression patterns are choreographed.
Authors
- Waclaw, Bartlomiej ;
- Cholewa-Waclaw, Justyna ;
- Shah, Ruth ;
- Webb, Shaun ;
- Chhatbar, Kashyap ;
- Ramsahoye, Bernard ;
- Pusch, Oliver ;
- Yu, Miao ;
- Greulich, Philip ;
- Bird, Adrian
Supplementary data showing protein names, SILAC ratios (more than two-fold), peptide counts, and peptide intensities identified by SILAC MS in wild-type and TRIM25 KO HeLa cells. (XLSX 33 kb)
Authors
- Choudhury, Nila ;
- Heikel, Gregory ;
- Trubitsyna, Maryia ;
- Kubik, Peter ;
- Nowak, Jakub ;
- Webb, Shaun ;
- Granneman, Sander ;
- Spanos, Christos ;
- Rappsilber, Juri ;
- Castello, Alfredo ;
- Gracjan Michlewski
Supplementary data showing gene names and number of RNA reads derived from three independent T7-TRIM25 CLIP-seq experiments. (XLSX 117 kb)
Authors
- Choudhury, Nila ;
- Heikel, Gregory ;
- Trubitsyna, Maryia ;
- Kubik, Peter ;
- Nowak, Jakub ;
- Webb, Shaun ;
- Granneman, Sander ;
- Spanos, Christos ;
- Rappsilber, Juri ;
- Castello, Alfredo ;
- Gracjan Michlewski
Supplementary data showing protein names, SILAC ratios, peptide counts, and peptide intensities identified by SILAC MS in T7-TRIM25, T7-TRIM25Î RBD, and T7-TRIM25â +â RNases co-immunoprecipitation assays. (XLSX 22 kb)
Authors
- Choudhury, Nila ;
- Heikel, Gregory ;
- Trubitsyna, Maryia ;
- Kubik, Peter ;
- Nowak, Jakub ;
- Webb, Shaun ;
- Granneman, Sander ;
- Spanos, Christos ;
- Rappsilber, Juri ;
- Castello, Alfredo ;
- Gracjan Michlewski
Supplementary data showing protein names, SILAC ratios (more than two-fold), peptide counts, and peptide intensities identified by SILAC MS in wild-type and TRIM25 KO HeLa cells. (XLSX 33 kb)
Authors
- Choudhury, Nila ;
- Heikel, Gregory ;
- Trubitsyna, Maryia ;
- Kubik, Peter ;
- Nowak, Jakub ;
- Webb, Shaun ;
- Granneman, Sander ;
- Spanos, Christos ;
- Rappsilber, Juri ;
- Castello, Alfredo ;
- Gracjan Michlewski
Supplementary data showing protein names, SILAC ratios, peptide counts, and peptide intensities identified by SILAC MS in T7-TRIM25, T7-TRIM25Î RBD, and T7-TRIM25â +â RNases co-immunoprecipitation assays. (XLSX 22 kb)
Authors
- Choudhury, Nila ;
- Heikel, Gregory ;
- Trubitsyna, Maryia ;
- Kubik, Peter ;
- Nowak, Jakub ;
- Webb, Shaun ;
- Granneman, Sander ;
- Spanos, Christos ;
- Rappsilber, Juri ;
- Castello, Alfredo ;
- Gracjan Michlewski
Supplementary data showing gene names and number of RNA reads derived from three independent T7-TRIM25 CLIP-seq experiments. (XLSX 117 kb)
Authors
- Choudhury, Nila ;
- Heikel, Gregory ;
- Trubitsyna, Maryia ;
- Kubik, Peter ;
- Nowak, Jakub ;
- Webb, Shaun ;
- Granneman, Sander ;
- Spanos, Christos ;
- Rappsilber, Juri ;
- Castello, Alfredo ;
- Gracjan Michlewski