Automated Author Profile

Spiwok, Vojtech

University of Chemistry and Technology, Prague

Current S-Index

3.5

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

1.8

Average Dataset Index per dataset

Total Datasets

2

Total datasets for this author

Average FAIR Score

82.7%

Average FAIR Score per dataset

Total Citations

2

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Free-Energy Surface Prediction by Flying Gaussian Method: Numerical Proof

Biomolecular simulations have a great potential in protein engineering, drug discovery and many other fields. Unfortunately, this method is computationally expensive, so many interesting processes cannot be routinely studied. In order to address this problem we developed Flying Gaussian method [Journal of Chemical Theory and Computation 12, 4644-4650 (2016)]. This method simultaneously simulates multiple replicas of the studied system and disfavor replicas with similar structures by artificial bias potential. The question arises how to calculate an unbiased free energy surface from a biased simulation. This dataset demonstrates together with mathematical arguments supports application of Umbrella Sampling reweighing method, despite the fact that this method is designed for methods with a time-independent bias potential.

Authors

  • Spiwok, Vojtech ;
  • Šućur, Zoran ;
  • Kříž, Pavel
1 Citation0 Mentions88% FAIR1.3 Dataset Index
10.24435/materialscloud:2019.0013/v1April 2019

Free-Energy Surface Prediction by Flying Gaussian Method: Numerical Proof

Biomolecular simulations have a great potential in protein engineering, drug discovery and many other fields. Unfortunately, this method is computationally expensive, so many interesting processes cannot be routinely studied. In order to address this problem we developed Flying Gaussian method [Journal of Chemical Theory and Computation 12, 4644-4650 (2016)]. This method simultaneously simulates multiple replicas of the studied system and disfavor replicas with similar structures by artificial bias potential. The question arises how to calculate an unbiased free energy surface from a biased simulation. This dataset demonstrates together with mathematical arguments supports application of Umbrella Sampling reweighing method, despite the fact that this method is designed for methods with a time-independent bias potential.

Authors

  • Spiwok, Vojtech ;
  • Šućur, Zoran ;
  • Kříž, Pavel
1 Citation0 Mentions77% FAIR2.2 Dataset Index
10.24435/materialscloud:vq-vfApril 2019