This dataset contains the digitized treatments in Plazi based on the original journal article Zhang, Ren-Bo, Deng, Tan, Liu, Ying, Xie, Da-Jun, Wei, Ruo-Xun, He, Lin, Dou, Quan-Li, Qian, Zheng-Min (2025): Sinosenecio tongziensis (Asteraceae), a new species from north Guizhou, China. PhytoKeys 252: 187-196, DOI: 10.3897/phytokeys.252.141719

The 19S regulatory particle (RP) of the proteasome is emerging as a promising target for the treatment of myeloma that are resistant to bortezomib, a selective inhibitor of the 20S core particle. However, the molecular basis underlying the targeting of the 19S RP for myeloma therapy remains to be elucidated. Here we report that, unexpectedly, the 19S RP component PSMD14 is physically associated with the myeloma driver, NSD2 on chromatin independent of 19S RP. We find that PSMD14 is a histone deubiquitinase acting on H2AK119, and that PSMD14-catalyzed H2AK119 deubiquitination facilitates NSD2-directed H3K36 di-methylation. Integrative genomic and epigenomic analyses reveal that the functional coordination between PSMD14 and NSD2 is associated with transcription activation of a cohort of genes including RELA that are critically involved in myelomagenesis. We show that RELA, in turn, transactivates PSMD14, establishing a positive feedback regulatory loop that explains well the long-reported clinical behaviours of myeloma. Chemical inhibition of PSMD14 sensitizes myeloma cells to bortezomib and confers a synergistic anti-myeloma activity with bortezomib, lenalidomide and dexamethasone. Importantly, the expression of PSMD14 is increasingly elevated as asymptomatic pre-malignant myeloma progresses to multiple myeloma, and its level of expression is inversely correlated with the overall survival and bortezomib-based therapeutic response of myeloma patients. Our study uncovers an unappreciated function of PSMD14 as an epigenetic regulator and a myeloma driver, supporting the pursuit of this proteasome constituent as a therapeutic target to overcome the treatment limitation of myeloma.

The 19S regulatory particle (RP) of the proteasome is emerging as a promising target for the treatment of myeloma that are resistant to bortezomib, a selective inhibitor of the 20S core particle. However, the molecular basis underlying the targeting of the 19S RP for myeloma therapy remains to be elucidated. Here we report that, unexpectedly, the 19S RP component PSMD14 is physically associated with the myeloma driver, NSD2 on chromatin independent of 19S RP. We find that PSMD14 is a histone deubiquitinase acting on H2AK119, and that PSMD14-catalyzed H2AK119 deubiquitination facilitates NSD2-directed H3K36 di-methylation. Integrative genomic and epigenomic analyses reveal that the functional coordination between PSMD14 and NSD2 is associated with transcription activation of a cohort of genes including RELA that are critically involved in myelomagenesis. We show that RELA, in turn, transactivates PSMD14, establishing a positive feedback regulatory loop that explains well the long-reported clinical behaviours of myeloma. Chemical inhibition of PSMD14 sensitizes myeloma cells to bortezomib and confers a synergistic anti-myeloma activity with bortezomib, lenalidomide and dexamethasone. Importantly, the expression of PSMD14 is increasingly elevated as asymptomatic pre-malignant myeloma progresses to multiple myeloma, and its level of expression is inversely correlated with the overall survival and bortezomib-based therapeutic response of myeloma patients. Our study uncovers an unappreciated function of PSMD14 as an epigenetic regulator and a myeloma driver, supporting the pursuit of this proteasome constituent as a therapeutic target to overcome the treatment limitation of myeloma.

This dataset contains the digitized treatments in Plazi based on the original journal article Deng, Tan, Wen, Fang, Xie, Da-Jun, Wei, Ruo-Xun, He, Lin, Dou, Quan-Li, Qian, Zheng-Min, Zhang, Ren-Bo (2023): Paraboea zunyiensis (Gesneriaceae), a new species from north Guizhou, China. PhytoKeys 235: 21-29, DOI: http://dx.doi.org/10.3897/phytokeys.235.111412, URL: http://dx.doi.org/10.3897/phytokeys.235.111412

This dataset contains the digitized treatments in Plazi based on the original journal article He, Lin, Cheng, Hong, Zhao, Lin, Htun, Aye Aye, Yu, Zhi He, Deng, Jian Xin, Li, Qi Li (2021): Morphological and molecular identification of two new Alternaria species (Ascomycota, Pleosporaceae) in section Radicina from China. MycoKeys 78: 187-198, DOI: http://dx.doi.org/10.3897/mycokeys.78.64853, URL: http://dx.doi.org/10.3897/mycokeys.78.64853

Table 1. Comparing the diagnostics of Paraphlomis kuankuoshuiensis sp. nov., P. patentisetulosa, P. hispida, and P. hirsutissima.Note: question mark (?) indicates that that character is not described in the references.TraitsP. kuankuoshuiensis sp. nov.P. patentisetulosaP. hispidaP. hirsutissimaStemsHeight (cm)2-715-25Ca. 60> 20HabitErect and tuftedAscendingSlightly ascendingFlexuousHabitatSteep rock surface beside streamBeside streamIn tropical forests or thicketsIn gravels below tropical forestsLeaf blades (cm)10- 37 × 3-85.5-14.5 × 2.5-73-20 × 1.8-11.55.5-13 × 2-5Fruiting calycesShapeTubular-campanulateTubular-campanulateTubular-campanulateTubularLength (mm)5-6To 11Ca. 78-9HairsSparsely bristly, glabrous insideFinely bristly outsideDensely hispid, glabrous inside?Tooth length (mm)Ca. 2Ca. 3Ca. 5Ca. 2Tooth directionErectErectErectReflexedNutlet apicesTruncateRoundedTruncate?Fl.Jul-Aug???Fr.Aug-SepNovNov-JanJanDistributed province in ChinaGuizhouGuangdongYunnan [Vietnam]Yunnan

Table 1. Comparing the diagnostics of Paraphlomis kuankuoshuiensis sp. nov., P. patentisetulosa, P. hispida, and P. hirsutissima.Note: question mark (?) indicates that that character is not described in the references.TraitsP. kuankuoshuiensis sp. nov.P. patentisetulosaP. hispidaP. hirsutissimaStemsHeight (cm)2-715-25Ca. 60> 20HabitErect and tuftedAscendingSlightly ascendingFlexuousHabitatSteep rock surface beside streamBeside streamIn tropical forests or thicketsIn gravels below tropical forestsLeaf blades (cm)10- 37 × 3-85.5-14.5 × 2.5-73-20 × 1.8-11.55.5-13 × 2-5Fruiting calycesShapeTubular-campanulateTubular-campanulateTubular-campanulateTubularLength (mm)5-6To 11Ca. 78-9HairsSparsely bristly, glabrous insideFinely bristly outsideDensely hispid, glabrous inside?Tooth length (mm)Ca. 2Ca. 3Ca. 5Ca. 2Tooth directionErectErectErectReflexedNutlet apicesTruncateRoundedTruncate?Fl.Jul-Aug???Fr.Aug-SepNovNov-JanJanDistributed province in ChinaGuizhouGuangdongYunnan [Vietnam]Yunnan

This dataset contains the digitized treatments in Plazi based on the original journal article He, Lin, Liu, Hai Feng, Cui, Meng Jiao, Pei, Dong Fang, Du, Tao, Deng, Jian Xin (2020): Alternaria vicatiae sp. nov. (Ascomycota: Pleosporaceae) Isolated from Vicatia thibetica in China. Phytotaxa 439 (3): 255-264, DOI: 10.11646/phytotaxa.439.3.7, URL: http://dx.doi.org/10.11646/zootaxa.5360.3.8

This dataset contains the digitized treatments in Plazi based on the original journal article Zhang, Ren-Bo, Deng, Tan, Dou, Quan-Li, Wei, Ruo-Xun, He, Lin, Ma, Chong-Bo, Zhao, Sheng, Hu, Shun (2020): Paraphlomis kuankuoshuiensis (Lamiaceae), a new species from the limestone areas of northern Guizhou, China. PhytoKeys 139: 13-20, DOI: http://dx.doi.org/10.3897/phytokeys.139.47055, URL: http://dx.doi.org/10.3897/phytokeys.139.47055

This dataset contains the digitized treatments in Plazi based on the original journal article Zhang, Ren-Bo, Deng, Tan, Dou, Quan-Li, He, Lin, Lv, Xin-Yun, Jiang, Hong (2019): Sedum lipingense (Crassulaceae) identifying a new stonecrop species in SE Guizhou, China, based on morphological and molecular evidence. PhytoKeys 134: 125-133, DOI: http://dx.doi.org/10.3897/phytokeys.134.38287, URL: http://dx.doi.org/10.3897/phytokeys.134.38287