This data supports work looking at the effect of solvents on the particle size of liposomes during microfluidics manufacturing. This dataset contains data of particle size, PDI and zeta potential of several formulations investigated in this paper. Abstract: The aim of this work was to assess the impact of solvent selection on the microfluidic production of liposomes. To achieve this, liposomes were manufactured using small-scale and bench-scale microfluidics systems using three aqueous miscible solvents (ethanol, methanol or isopropanol, alone or in combination). Liposomes composed of different lipid compositions were manufactured with these different solvents and characterised to study the influence of solvents on liposomes attributes. Our studies demonstrate that solvent selection is a key consideration during the microfluidics manufacturing process, not only when considering lipid solubility but also with regard to the resultant liposome critical quality attributes. In general, reducing the polarity of the solvent (from methanol to IPA) increased the liposome particle size without impacting on liposome short-term stability. Furthermore, solvent combinations such as methanol/IPA mixtures can be used to modify solvent polarity and the resultant liposome particle size. However, the impact of solvent choice on the liposome product is influenced by the liposome formulation; liposomes containing charged lipids showed more sensitivity to solvent selection and formulations containing PEG were less influenced by the choice of solvent. Indeed, incorporation of 14 wt % or more of pegylated lipid was shown to negate the impact of solvent selection.