The objectives of this study were to 1) investigate the effects of Cognitive Academic Language Learning Approach on English oral communication ability of Bible College students 2) explore students’ opinions towards the components of CALLA. The participants were college students at Bangkok Bible Seminary. The Paired-Samples T-test was applied to investigate the differences between the mean scores from the pre and post English Oral Communication Ability Test. The interview was used to explore into the students’ opinion towards the CALLA. The results of the analyses revealed that there was a significant difference between the mean scores from the pre and posttest. In other words, the Bible college students improved their English oral communication ability after the use of CALLA. The result of the interview showed both positive and negative opinions towards the components of CALLA which are content, language, and strategy as well as the instructional process. The interview showed that the impacts of the English oral communication ability of the students are the content motivation, their confidence and willingness to communicate, the use of strategies, as well as, the collaboration in class activities.