Dry devolatilization is a promising method for saving energy, but understanding the devolatilization process has been challenging. A static devolatilizer was designed to study the devolatilization process of a Styrene-butadiene-styrene (SBS) block copolymer solution at different temperatures using visualization technology. The study found that temperature, Reynolds number, and heat flux are key factors influencing the devolatilization process. The optimal residence time was determined to be 196 s and the suitable feed coefficient is 0.17. Additionally, a new dimensionless parameter (the LZ number) was introduced. A value closer to 1 indicated a more effective devolatilization process. The obtained thermodynamic parameters and LZ number can guide the design of industrial devolatilization devices.

Dry devolatilization is a promising method for saving energy, but understanding the devolatilization process has been challenging. A static devolatilizer was designed to study the devolatilization process of a Styrene-butadiene-styrene (SBS) block copolymer solution at different temperatures using visualization technology. The study found that temperature, Reynolds number, and heat flux are key factors influencing the devolatilization process. The optimal residence time was determined to be 196 s and the suitable feed coefficient is 0.17. Additionally, a new dimensionless parameter (the LZ number) was introduced. A value closer to 1 indicated a more effective devolatilization process. The obtained thermodynamic parameters and LZ number can guide the design of industrial devolatilization devices.

Supplemental Figure 1. Differential allelic transcription factor binding activities in peripheral blood mononuclear cells (PBMCs) This figure depicts electrophoretic mobility shift assays (EMSA) analysis meant to characterise the binding properties of the risk allele vs. non-risk allele to nuclear protein extract (NE) from PBMCs and interacting protein of NE and antibody, respectively. EMSA were performed using 5`biotinylated probes corresponding to location including rs3024490 (A, B, C, D and E), rs1518110 (F, G) and rs1554286 (H). (A), (B), (C), (D) and (E) show no special binding for the rs3024490 T-allele or G-allele with interacting protein of NE and anti-TBX21, NE and anti-TBX15, NE and anti-MGA, NE and anti-TBX4 or NE and anti-TBX5, respectively. (F) and (G) show no special binding for the rs1518110 T-allele or G-allele with interacting protein of NE and anti-LMX1A or NE and anti-LMX1B, respectively. (H) shows no binding for the rs1554286 T-allele or C-allele with interacting protein of NE and anti-NFATC3. Supplemental Figure 2. Epigenomic profiling identifies rs3024490 and linkage disequilibrium (LD) single nucleotide polymorphisms (SNPs) as candidate functional SNPs Associated variants rs3024490 and LD SNPs (hg19 chr1:206944233-206946634) are plotted with the ENCODE (top) and the Roadmap Epigenomics project (bottom) tracking for peripheral blood mononuclear cells. Rs3024490 and LD SNPs were annotated as “enhancer SNPs” based on a 25-state model predicted by histone-modified ChromHMM (top) and H3K27ac and H3K4Me1 enhancer-specific enrichments (bottom). Supplemental Table 1. DNA sequence designed for primers of luciferase gene-reporter assay Supplemental Table 2. The basic characteristics of all subjects Supplemental Table 3. Variants linked to rs3024490 in 1000 GENOMES: phase_3: CHB Supplemental Table 4. Variants linked to rs3024490 in 1000 GENOMES: phase_3: CHS Supplemental Table 5. A list of TFs from JASPAR predicted to bind similar DNA motifs containing alleles Supplemental Table 6. A list of TFs predicted to bind only a similar DNA motif containing rs3024490-G Supplemental Table 7. A list of TFs predicted to bind only a similar DNA motif containing rs1518110-T Supplemental Table 8. Alist of TFs predicted to bind only a similar DNA motif containing rs1554286-T

Supplemental Figure 1. Differential allelic transcription factor binding activities in peripheral blood mononuclear cells (PBMCs) This figure depicts electrophoretic mobility shift assays (EMSA) analysis meant to characterise the binding properties of the risk allele vs. non-risk allele to nuclear protein extract (NE) from PBMCs and interacting protein of NE and antibody, respectively. EMSA were performed using 5`biotinylated probes corresponding to location including rs3024490 (A, B, C, D and E), rs1518110 (F, G) and rs1554286 (H). (A), (B), (C), (D) and (E) show no special binding for the rs3024490 T-allele or G-allele with interacting protein of NE and anti-TBX21, NE and anti-TBX15, NE and anti-MGA, NE and anti-TBX4 or NE and anti-TBX5, respectively. (F) and (G) show no special binding for the rs1518110 T-allele or G-allele with interacting protein of NE and anti-LMX1A or NE and anti-LMX1B, respectively. (H) shows no binding for the rs1554286 T-allele or C-allele with interacting protein of NE and anti-NFATC3. Supplemental Figure 2. Epigenomic profiling identifies rs3024490 and linkage disequilibrium (LD) single nucleotide polymorphisms (SNPs) as candidate functional SNPs Associated variants rs3024490 and LD SNPs (hg19 chr1:206944233-206946634) are plotted with the ENCODE (top) and the Roadmap Epigenomics project (bottom) tracking for peripheral blood mononuclear cells. Rs3024490 and LD SNPs were annotated as “enhancer SNPs” based on a 25-state model predicted by histone-modified ChromHMM (top) and H3K27ac and H3K4Me1 enhancer-specific enrichments (bottom). Supplemental Table 1. DNA sequence designed for primers of luciferase gene-reporter assay Supplemental Table 2. The basic characteristics of all subjects Supplemental Table 3. Variants linked to rs3024490 in 1000 GENOMES: phase_3: CHB Supplemental Table 4. Variants linked to rs3024490 in 1000 GENOMES: phase_3: CHS Supplemental Table 5. A list of TFs from JASPAR predicted to bind similar DNA motifs containing alleles Supplemental Table 6. A list of TFs predicted to bind only a similar DNA motif containing rs3024490-G Supplemental Table 7. A list of TFs predicted to bind only a similar DNA motif containing rs1518110-T Supplemental Table 8. Alist of TFs predicted to bind only a similar DNA motif containing rs1554286-T

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An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

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