Raw transparency data file containing the information used the study “Noradrenergic circuit control of non-REM sleep substates” (Osorio-Forero, Cardis, Vantomme, Guillaume-Gentil, Katsioudi, Devenoges, Fernandez, Lüthi). Here you can find the raw data used for the effects of blockage of in-vivo or in-vitro noradrenergic signaling in the thalamus in sleep spindles clustering and cellular mechanisms. The effects on sleep spindles and sigma activity upon optogenetic stimulation of Locus coeruleus (LC) cells bodies, thalamic or somatosensory cortical LC terminals during non-rapid-eye movement sleep as well as the optogenetic inhibition of the LC bodies. Additionally, you can find the Information about the LC fiber density within the thalamus and somatosensory cortex. The effects on heart rate upon optogenetic stimulation of LC cell bodies is also included in the dataset.

Raw transparency data file containing the information used the study “Noradrenergic circuit control of non-REM sleep substates” (Osorio-Forero, Cardis, Vantomme, Guillaume-Gentil, Katsioudi, Devenoges, Fernandez, Lüthi). Here you can find the raw data used for the effects of blockage of in-vivo or in-vitro noradrenergic signaling in the thalamus in sleep spindles clustering and cellular mechanisms. The effects on sleep spindles and sigma activity upon optogenetic stimulation of Locus coeruleus (LC) cells bodies, thalamic or somatosensory cortical LC terminals during non-rapid-eye movement sleep as well as the optogenetic inhibition of the LC bodies. Additionally, you can find the Information about the LC fiber density within the thalamus and somatosensory cortex. The effects on heart rate upon optogenetic stimulation of LC cell bodies is also included in the dataset.

As we navigate in space, external landmarks and internal information guide our movement. Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals remain, however, unclear. We identify an excitatory synaptic projection from the presubiculum (PreS) and the multisensory-associative retrosplenial cortex (RSC) to the anterodorsal thalamic reticular nucleus (TRN), so far classically implied in gating sensory information flow. In vitro, projections to TRN involve AMPA/NMDA-type glutamate receptors that initiate TRN cell burst discharge and feedforward inhibition of anterior thalamic nuclei. In vivo, chemogenetic anterodorsal TRN inhibition modulates PreS/RSC-induced anterior thalamic firing dynamics, broadens the tuning of thalamic HD cells, and lead to preferential use of allo- over egocentric search strategies in the Morris water maze. TRN-dependent thalamic inhibition is thus an integral part of limbic navigational circuits wherein it coordinates external sensory and internal HD signals to regulate the choice of search strategies during spatial navigation.

As we navigate in space, external landmarks and internal information guide our movement. Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals remain, however, unclear. We identify an excitatory synaptic projection from the presubiculum (PreS) and the multisensory-associative retrosplenial cortex (RSC) to the anterodorsal thalamic reticular nucleus (TRN), so far classically implied in gating sensory information flow. In vitro, projections to TRN involve AMPA/NMDA-type glutamate receptors that initiate TRN cell burst discharge and feedforward inhibition of anterior thalamic nuclei. In vivo, chemogenetic anterodorsal TRN inhibition modulates PreS/RSC-induced anterior thalamic firing dynamics, broadens the tuning of thalamic HD cells, and lead to preferential use of allo- over egocentric search strategies in the Morris water maze. TRN-dependent thalamic inhibition is thus an integral part of limbic navigational circuits wherein it coordinates external sensory and internal HD signals to regulate the choice of search strategies during spatial navigation.