Automated Author Profile

Rovó, Zita

University of Lausanne

Current S-Index

3.6

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

1.8

Average Dataset Index per dataset

Total Datasets

2

Total datasets for this author

Average FAIR Score

73.1%

Average FAIR Score per dataset

Total Citations

0

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

DATA: A thalamic reticular circuit for head direction cell tuning and spatial navigation

As we navigate in space, external landmarks and internal information guide our movement. Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals remain, however, unclear. We identify an excitatory synaptic projection from the presubiculum (PreS) and the multisensory-associative retrosplenial cortex (RSC) to the anterodorsal thalamic reticular nucleus (TRN), so far classically implied in gating sensory information flow. In vitro, projections to TRN involve AMPA/NMDA-type glutamate receptors that initiate TRN cell burst discharge and feedforward inhibition of anterior thalamic nuclei. In vivo, chemogenetic anterodorsal TRN inhibition modulates PreS/RSC-induced anterior thalamic firing dynamics, broadens the tuning of thalamic HD cells, and lead to preferential use of allo- over egocentric search strategies in the Morris water maze. TRN-dependent thalamic inhibition is thus an integral part of limbic navigational circuits wherein it coordinates external sensory and internal HD signals to regulate the choice of search strategies during spatial navigation.

Authors

  • Vantomme, Gil ;
  • Rovó, Zita ;
  • Cardis, Romain ;
  • Béard, Elidie ;
  • Katsioudi, Georgia ;
  • Guadagno, Angelo ;
  • Perrenoud, Virginie ;
  • Fernandez, Laura MJ ;
  • Lüthi, Anita
0 Citations0 Mentions73% FAIR1.8 Dataset Index
10.5281/zenodo.3819213May 2020

DATA: A thalamic reticular circuit for head direction cell tuning and spatial navigation

As we navigate in space, external landmarks and internal information guide our movement. Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals remain, however, unclear. We identify an excitatory synaptic projection from the presubiculum (PreS) and the multisensory-associative retrosplenial cortex (RSC) to the anterodorsal thalamic reticular nucleus (TRN), so far classically implied in gating sensory information flow. In vitro, projections to TRN involve AMPA/NMDA-type glutamate receptors that initiate TRN cell burst discharge and feedforward inhibition of anterior thalamic nuclei. In vivo, chemogenetic anterodorsal TRN inhibition modulates PreS/RSC-induced anterior thalamic firing dynamics, broadens the tuning of thalamic HD cells, and lead to preferential use of allo- over egocentric search strategies in the Morris water maze. TRN-dependent thalamic inhibition is thus an integral part of limbic navigational circuits wherein it coordinates external sensory and internal HD signals to regulate the choice of search strategies during spatial navigation.

Authors

  • Vantomme, Gil ;
  • Rovó, Zita ;
  • Cardis, Romain ;
  • Béard, Elidie ;
  • Katsioudi, Georgia ;
  • Guadagno, Angelo ;
  • Perrenoud, Virginie ;
  • Fernandez, Laura MJ ;
  • Lüthi, Anita
0 Citations0 Mentions73% FAIR1.8 Dataset Index
10.5281/zenodo.3819212May 2020