The data deposited here come from the work entitled "Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians." by Isabela Espasandin1*, Cynthia Chester Cardoso2, Thyago Leal-Calvo3, Mayara Abud Mendes1, Ana Carla Pereira Latini4, Samuel Henrique Malcher de Castro5, André Luiz Leturiondo5, Ohanna C. L. Bezerra6, Roberta Olmo Pinheiro1, Anna Maria Sales1, Milton Ozório Moraes1†¶ and Fernanda de Souza Gomes Kehdy1¶1 Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil2 Molecular Virology Laboratory, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil3 University of California Berkeley, Innovative Genomics Institute, Berkeley, California, USA4 Research and Teaching Division, Lauro de Souza Lima Institute, Bauru, São Paulo, Brazil5 Laboratory of Molecular Biology, Alfredo da Matta Hospital Foundation, Manaus, Amazonas, Brazil6 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada* Corresponding authorEmail: [email protected]† Deceased¶ These authors contributed equally to this work and are sharing the last authorship. The zipped folder contains 5 files:- the dataset used in the case-control association analysis for the population of Rio de Janeiro, containing all the variables mentioned in the article (genotypes_dataset_riodejaneiro.csv);- the dataset used in the case-control association analysis for the population of Manaus, containing all the variables mentioned in the article (genotypes_dataset_manaus.csv);- the dataset used in the case-control association analysis for the population of Rondonopolis, containing all the variables mentioned in the article (genotypes_dataset_rondonopolis.csv);- the dataset used for the expression analyses involving skin biopsies, as described and containing all the variables mentioned in the article (expression_RNAseq_skinbiopsies_data.xlsx);- the dataset used for the expression analyses involving whole blood samples (paxgene), as described and containing all the variables mentioned in the article (expression_qPCR_paxgene_totalblood_data.xlsx);- the dataset used for the expression analyses involving macrophages before and after infection with live M. leprae, as described and containing all the variables mentioned in the article (expression_macrophages_CACNA2D3_data.xlsx);

The data deposited here come from the work entitled "Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians." by Isabela Espasandin1*, Cynthia Chester Cardoso2, Thyago Leal-Calvo3, Mayara Abud Mendes1, Ana Carla Pereira Latini4, Samuel Henrique Malcher de Castro5, André Luiz Leturiondo5, Ohanna C. L. Bezerra6, Roberta Olmo Pinheiro1, Anna Maria Sales1, Milton Ozório Moraes1†¶ and Fernanda de Souza Gomes Kehdy1¶1 Leprosy Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil2 Molecular Virology Laboratory, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil3 University of California Berkeley, Innovative Genomics Institute, Berkeley, California, USA4 Research and Teaching Division, Lauro de Souza Lima Institute, Bauru, São Paulo, Brazil5 Laboratory of Molecular Biology, Alfredo da Matta Hospital Foundation, Manaus, Amazonas, Brazil6 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada* Corresponding authorEmail: [email protected]† Deceased¶ These authors contributed equally to this work and are sharing the last authorship. The zipped folder contains 5 files:- the dataset used in the case-control association analysis for the population of Rio de Janeiro, containing all the variables mentioned in the article (genotypes_dataset_riodejaneiro.csv);- the dataset used in the case-control association analysis for the population of Manaus, containing all the variables mentioned in the article (genotypes_dataset_manaus.csv);- the dataset used in the case-control association analysis for the population of Rondonopolis, containing all the variables mentioned in the article (genotypes_dataset_rondonopolis.csv);- the dataset used for the expression analyses involving skin biopsies, as described and containing all the variables mentioned in the article (expression_RNAseq_skinbiopsies_data.xlsx);- the dataset used for the expression analyses involving whole blood samples (paxgene), as described and containing all the variables mentioned in the article (expression_qPCR_paxgene_totalblood_data.xlsx);- the dataset used for the expression analyses involving macrophages before and after infection with live M. leprae, as described and containing all the variables mentioned in the article (expression_macrophages_CACNA2D3_data.xlsx);

Data and metadata for the publication: "Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations" by Bezerra et al. 2020. Please, see README.rmd for more information. Search engine additional keywords: rs11264355, rs1052176, rs4620533, rs4971072, rs11264359, leprosy, TaqMan SNP Genotyping

Data and metadata for the publication: "Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations" by Bezerra et al. 2020. Please, see README.rmd for more information. Search engine additional keywords: rs11264355, rs1052176, rs4620533, rs4971072, rs11264359, leprosy, TaqMan SNP Genotyping