Automated Author ProfileFederico, Aniello
Federico, Aniello
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 0.5 (sum of 1 dataset Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
In this manuscript, we show that FOXD1 is highly expressed in melanoma cells and is associated with a poor survival in patients with metastatic melanoma. FOXD1 can promote melanoma cells resistance to vemurafenib (BRAF inhibitor) or vemurafenib and cobimetinib (MEK inhibitor) combination treatment. whereas, loss of FOXD1 increases cell sensitivity to the targeted therapy. Interestingly, we identified the connective tissue growth factor (CTGF) to be a downstream factor of FOXD1. FOXD1 can promote cell resistance by regulating CTGF expression. Based on these findings, we conclude that FOXD1 might be a promising new diagnostic marker and a therapeutic target for the treatment of targeted therapy resistant melanoma.
Authors
- Sun, Qian ;
- Novak, Daniel ;
- Hüser, Laura ;
- Poelchen, Juliane ;
- Huizi Wu ;
- Granados, Karol ;
- Federico, Aniello ;
- Liu, Ke ;
- Steinfass, Tamara ;
- Vierthaler, Marlene ;
- Umansky, Viktor ;
- Utikal, Jochen