In the present study, the authors performed genome-wide SNP typing of 55 Malagasy samples with the Infinium Multi-Ethnic Genotyping Array (MEGA) and analyzed data with a focus on a set of 28 pharmacogenes (Supplementary Table 1).QC steps were followed as recommended by Illumina [42,45] and have been described by various authors [46,47] (Supplementary Document 1). The MAF distribution of the polymorphic SNPs in four classes (rare, <1%; low, 1–5%; moderate, >5–10%; and high, >10%) is presented in Supplementary Table 2For the polymorphic SNPs, their locations, SNP IDs, genomic sequence positions and variant impacts, the star alleles/suballeles they represent and their MAFs, are presented in Supplementary Table 3 in chromosomal order.The majority of these SNPs are intronic (n = 384), whereas 110 are in coding regions or impact splicing; the latter are presented separately in Supplementary Table 4.Their distribution, CNV confidence scores and sizes are presented in Supplementary Table 5.The same CNVs were identified in more than one Malagasy sample; examples and selected results are presented in Supplementary Table 6

In the present study, the authors performed genome-wide SNP typing of 55 Malagasy samples with the Infinium Multi-Ethnic Genotyping Array (MEGA) and analyzed data with a focus on a set of 28 pharmacogenes (Supplementary Table 1).QC steps were followed as recommended by Illumina [42,45] and have been described by various authors [46,47] (Supplementary Document 1). The MAF distribution of the polymorphic SNPs in four classes (rare, <1%; low, 1–5%; moderate, >5–10%; and high, >10%) is presented in Supplementary Table 2For the polymorphic SNPs, their locations, SNP IDs, genomic sequence positions and variant impacts, the star alleles/suballeles they represent and their MAFs, are presented in Supplementary Table 3 in chromosomal order.The majority of these SNPs are intronic (n = 384), whereas 110 are in coding regions or impact splicing; the latter are presented separately in Supplementary Table 4.Their distribution, CNV confidence scores and sizes are presented in Supplementary Table 5.The same CNVs were identified in more than one Malagasy sample; examples and selected results are presented in Supplementary Table 6

Figure S1 is the Epistatic interaction between loci on chromosome 6 regulate red cell distribution width in blood. Figure S2 Main Effect mRNA Expression of Extl1 and Cadps2. Figure S3 is Interaction Effect mRNA Expression of Tmem245.Table S1 is the raw genotype data, S2 is the raw trait data file, S5 is the RNA seq main effects results, S6 is the RNA Seq Interaction results, and S7 is the gene ontology.

Figure S1 is the Epistatic interaction between loci on chromosome 6 regulate red cell distribution width in blood. Figure S2 Main Effect mRNA Expression of Extl1 and Cadps2. Figure S3 is Interaction Effect mRNA Expression of Tmem245.Table S1 is the raw genotype data, S2 is the raw trait data file, S5 is the RNA seq main effects results, S6 is the RNA Seq Interaction results, and S7 is the gene ontology.