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Every year, millions of heart attacks happen around the world. But up to 78% of them are undiagnosed or “silent”. This means a large fraction of people with heart attack never get the cocktail of drugs known to save lives, by preventing future heart attacks and sudden death. Today, doctors can order tests (like MRIs or ultrasounds) to diagnose patients when they suspect a prior heart attack. But the reason so many heart attacks remain silent is precisely because doctors and patients don’t even suspect a heart attack has happened. Finding new ways to diagnose these undiagnosed heart attacks at scale could dramatically expand access to life-saving medications. And because of our close partnership with the county health system that sourced these data, algorithms developed on the platform, once validated, have a clear pathway for making it into clinical use and helping real patients. Electrocardiograms (ECGs) are a cheap, widespread test done everywhere in the health care system: during annual checkups, ER visits, before surgical procedures, etc. Doctors have learned to diagnose some limited signs of prior heart attack on ECGs (like ‘Q waves’), but these coarse findings still miss about 80% of prior heart attacks. We know that algorithms can match human performance on ECG interpretation—but could they do better, by systematically mining ECG waveforms for signals that might identify prior heart attacks? We don’t know, because there have not historically been datasets linking ECGs to high-quality labels on prior heart attack.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.