Summary
Thismetadata record provides details of the data supporting the claims of therelated article: “Genetic interactions among Brca1,Brca2, Palb2 and Trp53 in mammary tumor development”.Therelated study conducted parallel conditional knockout (CKO) of Brca1, Palb2 andBrca2, individually and in combination, along with one copy of Trp53, in themammary gland of nulliparous female mice in order to directly compare thelatency and penetrance of tumour development associated with each gene and thehistopathological and genomic features of the mutant tumours in the samesetting. Type of data:whole exome sequencing, analyses of mouse mammary glands and cultured humancells; flow cytometrySubject ofdata: mouse of mixed background; DAOY cells from ATCCSample size:Number of mice used (n=~25 per genotype) was determined empirically. Number of tumours sequenced (n=5 per hostgenotype) was determined empirically and by available financial resources. DataaccessThe wholeexome sequencing data are openly available in the Sequence Read Archive via the following accession: https://identifiers.org/ncbi/insdc.sra:SRP199480(BioProject accession: PRJNA544737).Supplementary Table S1, which underliesFigure 1 and Table 1 of the related article, is shared openly with this datarecord in the Excel file ‘Table S1.xlsx’.Original blots underlying Figure 5 arealso shared openly with this data record in the PDF files ‘Figure S4.pdf’ and ‘FigureS5.pdf’. Corresponding author(s) for this studyBingXia, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, NewBrunswick, NJ 08903. Phone: +1 732-235-7410; Email: [email protected], Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY10065. Phone: +1 212-639-2332; Email: [email protected]
Ethics oversight IACUCof Rutgers Robert Wood Johnson Medical School

Summary
Thismetadata record provides details of the data supporting the claims of therelated article: “Genetic interactions among Brca1,Brca2, Palb2 and Trp53 in mammary tumor development”.Therelated study conducted parallel conditional knockout (CKO) of Brca1, Palb2 andBrca2, individually and in combination, along with one copy of Trp53, in themammary gland of nulliparous female mice in order to directly compare thelatency and penetrance of tumour development associated with each gene and thehistopathological and genomic features of the mutant tumours in the samesetting. Type of data:whole exome sequencing, analyses of mouse mammary glands and cultured humancells; flow cytometrySubject ofdata: mouse of mixed background; DAOY cells from ATCCSample size:Number of mice used (n=~25 per genotype) was determined empirically. Number of tumours sequenced (n=5 per hostgenotype) was determined empirically and by available financial resources. DataaccessThe wholeexome sequencing data are openly available in the Sequence Read Archive via the following accession: https://identifiers.org/ncbi/insdc.sra:SRP199480(BioProject accession: PRJNA544737).Supplementary Table S1, which underliesFigure 1 and Table 1 of the related article, is shared openly with this datarecord in the Excel file ‘Table S1.xlsx’.Original blots underlying Figure 5 arealso shared openly with this data record in the PDF files ‘Figure S4.pdf’ and ‘FigureS5.pdf’. Corresponding author(s) for this studyBingXia, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, NewBrunswick, NJ 08903. Phone: +1 732-235-7410; Email: [email protected], Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY10065. Phone: +1 212-639-2332; Email: [email protected]
Ethics oversight IACUCof Rutgers Robert Wood Johnson Medical School