Supplementary Table 1. Municipal pressure indices of all municipalities in the Campania Region Supplementary table 2. Identification of Clusters within the Impact Areas applicable to the geo-stratified recruitment plan as part of a monitoring study in the Campania Region Abstract: The Experimental Zooprophylactic Institute of Southern Italy (IstitutoZooprofilattico Sperimentale del Mezzogiorno – IZSM) is a public healthinstitution operating within the Italian National Health Service. Over the pastfive years, IZSM has promoted several researches and interventions in an effortto tackle the “Land of Fires” phenomenon, caused by the continued traffickingand uncontrolled incineration of waste that has affected some areas of Campaniafor decades. In this article, a mathematical model that generates amunicipality index of environmental pressure is presented. The model wasdeveloped by a multi-disciplinary team led by an environmental engineer, whichincluded researchers in the fields of veterinary and human medicine, biologyand computer science. This model mayserve as a geo-stratification tool useful for the design of human biomonitoringstudies, although it may also be employed for strategic planning of remediationprograms and public health interventions.

Supplementary Table 1. Municipal pressure indices of all municipalities in the Campania Region Supplementary table 2. Identification of Clusters within the Impact Areas applicable to the geo-stratified recruitment plan as part of a monitoring study in the Campania Region Abstract: The Experimental Zooprophylactic Institute of Southern Italy (IstitutoZooprofilattico Sperimentale del Mezzogiorno – IZSM) is a public healthinstitution operating within the Italian National Health Service. Over the pastfive years, IZSM has promoted several researches and interventions in an effortto tackle the “Land of Fires” phenomenon, caused by the continued traffickingand uncontrolled incineration of waste that has affected some areas of Campaniafor decades. In this article, a mathematical model that generates amunicipality index of environmental pressure is presented. The model wasdeveloped by a multi-disciplinary team led by an environmental engineer, whichincluded researchers in the fields of veterinary and human medicine, biologyand computer science. This model mayserve as a geo-stratification tool useful for the design of human biomonitoringstudies, although it may also be employed for strategic planning of remediationprograms and public health interventions.