Automated Author Profile

Ferla, Matteo P.

Current S-Index

6.9

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

1.7

Average Dataset Index per dataset

Total Datasets

4

Total datasets for this author

Average FAIR Score

79.8%

Average FAIR Score per dataset

Total Citations

0

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Nsp3 macrodomain of SARS-CoV-2 ; A Target Enabling Package (Version: 0)

The conserved macrodomain encoded as non-structural protein 3 (Nsp3 Mac1) is employed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to remove host-derived ribosylation, which is a post-translational modification involved in the production of antiviral cytokines. This TEP provides early tools to develop Nsp3 Mac1 inhibitors, including purification protocols of recombinant proteins, reproducible crystallisation condition suitable for X-ray crystallography fragment screening, biophysical (activity and binding) assays and over 200 fragment hits representing a wide range of chemotypes, that are a starting point for the development of more selective and potent compounds.

Authors

  • Schuller, Marion ;
  • Correy, Galen J. ;
  • Gahbauer, Stefan ;
  • Fearon, Daren ;
  • Taiasean Wu ;
  • Díaz, Roberto Efraín ;
  • Young, Iris D. ;
  • Martins, Luan Carvalho ;
  • Smith, Dominique H. ;
  • Schulze-Gahmen, Ursula ;
  • Owens, Tristan W. ;
  • Ishan Deshpande ;
  • Merz, Gregory E. ;
  • Aye C. Thwin ;
  • Biel, Justin T. ;
  • Peters, Jessica K. ;
  • Moritz, Michelle ;
  • Herrera, Nadia ;
  • Kratochvil, Huong T. ;
  • CRG Structural Biology Consortium ;
  • Aimon, Anthony ;
  • Bennett, James M. ;
  • Neto, Jose Brandao ;
  • Cohen, Aina E. ;
  • Dias, Alexandre ;
  • Douangamath, Alice ;
  • Dunnett, Louise ;
  • Fedorov, Oleg ;
  • Bezerra, Gustavo Arruda ;
  • Ferla, Matteo P. ;
  • Fuchs, Martin R. ;
  • Gorrie-Stone, Tyler J. ;
  • Holton, James M. ;
  • Johnson, Michael G. ;
  • Krojer, Tobias ;
  • Meigs, George ;
  • Powell, Ailsa J. ;
  • Rack, Johannes Gregor Matthias ;
  • Rangel, Victor L. ;
  • Russi, Silvia ;
  • Skyner, Rachael E. ;
  • Smith, Clyde A. ;
  • Soares, Alexei S. ;
  • Wierman, Jennifer L. ;
  • Zhu, Kang ;
  • O'Brien, Peter ;
  • Jura, Natalia ;
  • Ashworth, Alan ;
  • Irwin, John J. ;
  • Thompson, Michael C. ;
  • Gestwicki, Jason E. ;
  • Von Delft, Frank ;
  • Shoichet, Brian K. ;
  • Fraser, James S.
0 Citations0 Mentions81% FAIR1.8 Dataset Index
10.5281/zenodo.5256268June 2021

Nsp3 macrodomain of SARS-CoV-2 ; A Target Enabling Package (Version: 1)

The conserved macrodomain encoded as non-structural protein 3 (Nsp3 Mac1) is employed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to remove host-derived ribosylation, which is a post-translational modification involved in the production of antiviral cytokines. This TEP provides early tools to develop Nsp3 Mac1 inhibitors, including purification protocols of recombinant proteins, reproducible crystallisation condition suitable for X-ray crystallography fragment screening, biophysical (activity and binding) assays and over 200 fragment hits representing a wide range of chemotypes, that are a starting point for the development of more selective and potent compounds.

Authors

  • Schuller, Marion ;
  • Correy, Galen J. ;
  • Gahbauer, Stefan ;
  • Fearon, Daren ;
  • Taiasean Wu ;
  • Díaz, Roberto Efraín ;
  • Young, Iris D. ;
  • Martins, Luan Carvalho ;
  • Smith, Dominique H. ;
  • Schulze-Gahmen, Ursula ;
  • Owens, Tristan W. ;
  • Ishan Deshpande ;
  • Merz, Gregory E. ;
  • Aye C. Thwin ;
  • Biel, Justin T. ;
  • Peters, Jessica K. ;
  • Moritz, Michelle ;
  • Herrera, Nadia ;
  • Kratochvil, Huong T. ;
  • CRG Structural Biology Consortium ;
  • Aimon, Anthony ;
  • Bennett, James M. ;
  • Neto, Jose Brandao ;
  • Cohen, Aina E. ;
  • Dias, Alexandre ;
  • Douangamath, Alice ;
  • Dunnett, Louise ;
  • Fedorov, Oleg ;
  • Bezerra, Gustavo Arruda ;
  • Ferla, Matteo P. ;
  • Fuchs, Martin R. ;
  • Gorrie-Stone, Tyler J. ;
  • Holton, James M. ;
  • Johnson, Michael G. ;
  • Krojer, Tobias ;
  • Meigs, George ;
  • Powell, Ailsa J. ;
  • Rack, Johannes Gregor Matthias ;
  • Rangel, Victor L. ;
  • Russi, Silvia ;
  • Skyner, Rachael E. ;
  • Smith, Clyde A. ;
  • Soares, Alexei S. ;
  • Wierman, Jennifer L. ;
  • Zhu, Kang ;
  • O'Brien, Peter ;
  • Jura, Natalia ;
  • Ashworth, Alan ;
  • Irwin, John J. ;
  • Thompson, Michael C. ;
  • Gestwicki, Jason E. ;
  • Von Delft, Frank ;
  • Shoichet, Brian K. ;
  • Fraser, James S.
0 Citations0 Mentions81% FAIR1.8 Dataset Index
10.5281/zenodo.5256267June 2021

Nsp3 macrodomain of SARS-CoV-2 ; A Target Enabling Package (Version: 1)

The conserved macrodomain encoded as non-structural protein 3 (Nsp3 Mac1) is employed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to remove host-derived ribosylation, which is a post-translational modification involved in the production of antiviral cytokines. This TEP provides early tools to develop Nsp3 Mac1 inhibitors, including purification protocols of recombinant proteins, reproducible crystallisation condition suitable for X-ray crystallography fragment screening, biophysical (activity and binding) assays and over 200 fragment hits representing a wide range of chemotypes, that are a starting point for the development of more selective and potent compounds.

Authors

  • Schuller, Marion ;
  • Correy, Galen J. ;
  • Gahbauer, Stefan ;
  • Fearon, Daren ;
  • Taiasean Wu ;
  • Díaz, Roberto Efraín ;
  • Young, Iris D. ;
  • Martins, Luan Carvalho ;
  • Smith, Dominique H. ;
  • Schulze-Gahmen, Ursula ;
  • Owens, Tristan W. ;
  • Ishan Deshpande ;
  • Merz, Gregory E. ;
  • Aye C. Thwin ;
  • Biel, Justin T. ;
  • Peters, Jessica K. ;
  • Moritz, Michelle ;
  • Herrera, Nadia ;
  • Kratochvil, Huong T. ;
  • CRG Structural Biology Consortium ;
  • Aimon, Anthony ;
  • Bennett, James M. ;
  • Neto, Jose Brandao ;
  • Cohen, Aina E. ;
  • Dias, Alexandre ;
  • Douangamath, Alice ;
  • Dunnett, Louise ;
  • Fedorov, Oleg ;
  • Bezerra, Gustavo Arruda ;
  • Ferla, Matteo P. ;
  • Fuchs, Martin R. ;
  • Gorrie-Stone, Tyler J. ;
  • Holton, James M. ;
  • Johnson, Michael G. ;
  • Krojer, Tobias ;
  • Meigs, George ;
  • Powell, Ailsa J. ;
  • Rack, Johannes Gregor Matthias ;
  • Rangel, Victor L. ;
  • Russi, Silvia ;
  • Skyner, Rachael E. ;
  • Smith, Clyde A. ;
  • Soares, Alexei S. ;
  • Wierman, Jennifer L. ;
  • Zhu, Kang ;
  • O'Brien, Peter ;
  • Jura, Natalia ;
  • Ashworth, Alan ;
  • Irwin, John J. ;
  • Thompson, Michael C. ;
  • Gestwicki, Jason E. ;
  • Von Delft, Frank ;
  • Shoichet, Brian K. ;
  • Fraser, James S.
0 Citations0 Mentions77% FAIR1.7 Dataset Index
10.5281/zenodo.5256296June 2021

Nsp3 macrodomain of SARS-CoV-2 ; A Target Enabling Package (Version: 1)

The conserved macrodomain encoded as non-structural protein 3 (Nsp3 Mac1) is employed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to remove host-derived ribosylation, which is a post-translational modification involved in the production of antiviral cytokines. This TEP provides early tools to develop Nsp3 Mac1 inhibitors, including purification protocols of recombinant proteins, reproducible crystallisation condition suitable for X-ray crystallography fragment screening, biophysical (activity and binding) assays and over 200 fragment hits representing a wide range of chemotypes, that are a starting point for the development of more selective and potent compounds.

Authors

  • Schuller, Marion ;
  • Correy, Galen J. ;
  • Gahbauer, Stefan ;
  • Fearon, Daren ;
  • Taiasean Wu ;
  • Díaz, Roberto Efraín ;
  • Young, Iris D. ;
  • Martins, Luan Carvalho ;
  • Smith, Dominique H. ;
  • Schulze-Gahmen, Ursula ;
  • Owens, Tristan W. ;
  • Ishan Deshpande ;
  • Merz, Gregory E. ;
  • Aye C. Thwin ;
  • Biel, Justin T. ;
  • Peters, Jessica K. ;
  • Moritz, Michelle ;
  • Herrera, Nadia ;
  • Kratochvil, Huong T. ;
  • CRG Structural Biology Consortium ;
  • Aimon, Anthony ;
  • Bennett, James M. ;
  • Neto, Jose Brandao ;
  • Cohen, Aina E. ;
  • Dias, Alexandre ;
  • Douangamath, Alice ;
  • Dunnett, Louise ;
  • Fedorov, Oleg ;
  • Bezerra, Gustavo Arruda ;
  • Ferla, Matteo P. ;
  • Fuchs, Martin R. ;
  • Gorrie-Stone, Tyler J. ;
  • Holton, James M. ;
  • Johnson, Michael G. ;
  • Krojer, Tobias ;
  • Meigs, George ;
  • Powell, Ailsa J. ;
  • Rack, Johannes Gregor Matthias ;
  • Rangel, Victor L. ;
  • Russi, Silvia ;
  • Skyner, Rachael E. ;
  • Smith, Clyde A. ;
  • Soares, Alexei S. ;
  • Wierman, Jennifer L. ;
  • Zhu, Kang ;
  • O'Brien, Peter ;
  • Jura, Natalia ;
  • Ashworth, Alan ;
  • Irwin, John J. ;
  • Thompson, Michael C. ;
  • Gestwicki, Jason E. ;
  • Von Delft, Frank ;
  • Shoichet, Brian K. ;
  • Fraser, James S.
0 Citations0 Mentions81% FAIR1.8 Dataset Index
10.5281/zenodo.5256368June 2021