Automated Author Profile

Martin, Thamires Oliveira Gasquez

Current S-Index

0.4

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

0.2

Average Dataset Index per dataset

Total Datasets

2

Total datasets for this author

Average FAIR Score

84.6%

Average FAIR Score per dataset

Total Citations

0

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

In vitro antimalarial activity of tigecycline against Plasmodium falciparum culture-adapted reference strains and clinical isolates from the Brazilian Amazon

Introduction: We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria. Methods: A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity. Results: The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI): 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug. Conclusions: Tigecycline may represent an alternative drug for the treatment of patients with severe malaria.

Authors

  • Ribatski-Silva, Daniele ;
  • Bassi, Carmen Lucia ;
  • Martin, Thamires Oliveira Gasquez ;
  • Alves-Junior, Eduardo ;
  • Gomes, Luciano Teixeira ;
  • Fontes, Cor Jésus Fernandes
0 Citations0 Mentions85% FAIR0.3 Dataset Index
10.6084/m9.figshare.199361052022

In vitro antimalarial activity of tigecycline against Plasmodium falciparum culture-adapted reference strains and clinical isolates from the Brazilian Amazon

Introduction: We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria. Methods: A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity. Results: The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI): 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug. Conclusions: Tigecycline may represent an alternative drug for the treatment of patients with severe malaria.

Authors

  • Ribatski-Silva, Daniele ;
  • Bassi, Carmen Lucia ;
  • Martin, Thamires Oliveira Gasquez ;
  • Alves-Junior, Eduardo ;
  • Gomes, Luciano Teixeira ;
  • Fontes, Cor Jésus Fernandes
0 Citations0 Mentions85% FAIR0.1 Dataset Index
10.6084/m9.figshare.19936105.v12022