Automated Author Profile

Songyi Zhou

1st Affiliated Hospital, Wenzhou Medical University

Current S-Index

0.1

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

0.1

Average Dataset Index per dataset

Total Datasets

1

Total datasets for this author

Average FAIR Score

15.4%

Average FAIR Score per dataset

Total Citations

1

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Antisense oligodeoxynucleotides against dynamin-related protein 1 reduce remifentanilinduced hyperalgesia by modulating spinal N-methyl-D-aspartate receptor expression in rats (Version: 1.0)

Spinal N-methyl-D-aspartate (NMDA) receptor activation is attributed to remifentanil-induced hyperalgesia (RIH). However, the specific mechanism and subsequent treatment is still unknown. Previous studies have shown that the dynamin-related protein 1 (DRP1)-mitochondria-reactive oxygen species (ROS) pathway playsan important role in neuropathic pain. This study examined whether antisense oligodeoxynucleotides against DRP1 (AS-DRP1) could reverse RIH. The authors first measured changes in paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) at 24 hours before remifentanil infusion and 4, 8, 24, and 48 hours after infusion. The expression levels of DRP1 and NR2B were measured after behavioral testing using Western blotting. In addition, DRP1 expression was knocked down by intrathecal administration of AS-DRP1 to investigate the effects of DRP1 on RIH. The behavioral testing, the expression levels of spinal DRP1 and NR2B, and dorsal mitochondrial superoxide were measured. Changes in mitochondrial morphology were assessed using electron microscopy.

Authors

  • Songyi Zhou ;
  • Yizhao Pan ;
  • Zhang, Yan ;
  • Lijun Gu ;
  • Leikai Ma ;
  • Qingqing Xu ;
  • Weijian Wang ;
  • Jiehao Sun
1 Citation0 Mentions15% FAIR0.4 Dataset Index
10.7910/dvn/ej82ij2023