An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Redox reactions are essential for various biological processes, hence, maintaining redox homeostasis is critical for cellular health and host–microbe interactions, particularly in marine invertebrates, where these processes remain poorly understood. This study investigates the role of the respiratory protein hemocyanin in regulating redox-related genes, reactive oxygen species (ROS) levels in shrimp hemocytes, and its influence on immune function and hemolymph Vibrio abundance. Our results show that hemocyanin is crucial in the regulation of the redox system, as hemocyanin knockdown disrupts the expression of antioxidant (PvPOD and PvGPX) and pro-oxidant (PvXOX) genes and redox enzyme activities, leading to elevated ROS levels in hemocytes. Additionally, we found that hemocyanin controls redox homeostasis in hemocytes through the p38-MAPK-c-Jun signaling pathway. Moreover, ROS levels regulated by hemocyanin via the MAPK pathway impacted on hemolymph Vibrio spp. abundance. These findings highlight a crucial role of hemocyanin as an antioxidant that modulates redox balance in shrimp hemocytes, with significant implications for immune defense and microbial homeostasis, offering new insights into antioxidative mechanisms in marine invertebrates.

Redox reactions are essential for various biological processes, hence, maintaining redox homeostasis is critical for cellular health and host–microbe interactions, particularly in marine invertebrates, where these processes remain poorly understood. This study investigates the role of the respiratory protein hemocyanin in regulating redox-related genes, reactive oxygen species (ROS) levels in shrimp hemocytes, and its influence on immune function and hemolymph Vibrio abundance. Our results show that hemocyanin is crucial in the regulation of the redox system, as hemocyanin knockdown disrupts the expression of antioxidant (PvPOD and PvGPX) and pro-oxidant (PvXOX) genes and redox enzyme activities, leading to elevated ROS levels in hemocytes. Additionally, we found that hemocyanin controls redox homeostasis in hemocytes through the p38-MAPK-c-Jun signaling pathway. Moreover, ROS levels regulated by hemocyanin via the MAPK pathway impacted on hemolymph Vibrio spp. abundance. These findings highlight a crucial role of hemocyanin as an antioxidant that modulates redox balance in shrimp hemocytes, with significant implications for immune defense and microbial homeostasis, offering new insights into antioxidative mechanisms in marine invertebrates.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Questionnaire data collected to investigate the factors influencing faculty members' intention to adopt asset management systems in Chinese public universities.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

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An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.