Scholar Data
Sign in

Automated Author Profile

Garcia-Manyes, Sergi

King's College London

Current S-Index

4.1

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

0.3

Average Dataset Index per dataset

Total Datasets

12

Total datasets for this author

Average FAIR Score

22.4%

Average FAIR Score per dataset

Total Citations

0

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Allosteric Activation of Vinculin by Talin [data]

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule magnetic tweezer experiments, Molecular Dynamics simulations, actin bundling assays, and adhesion assembly experiments in live cells, we here discover a two-ways allosteric network within vinculin as a regulator of the talin-vinculin interaction. We directly observe a maturation process of vinculin upon talin binding which reinforces the binding to talin at a rate of 0.03 s−1. This allosteric transition can compete with force-induced dissociation of vinculin from talin only at 7-10 pN. Mimicking the allosteric activation by mutation yields a vinculin molecule that bundles actin and localizes to focal adhesions in a force-independent manner. Hence, the allosteric switch confines talin-vinculin interactions and focal adhesion build-up to intermediate force levels. The ‘allosteric vinculin mutant’ is a valuable molecular tool to further dissect the mechanical and biochemical signalling circuits at focal adhesions and elsewhere.

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions100% FAIR1.1 Dataset Index
10.11588/data/wzdkt6January 2023

Fig4.tab

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.2 Dataset Index
10.11588/data/wzdkt6/ozhhslJanuary 2023

FigS6.tab

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.3 Dataset Index
10.11588/data/wzdkt6/rhgbbyJanuary 2023

Fig3.tab

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.2 Dataset Index
10.11588/data/wzdkt6/b12xrcJanuary 2023

FigS5.xlsx

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.4 Dataset Index
10.11588/data/wzdkt6/otrysoJanuary 2023

Fig1.tab

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.3 Dataset Index
10.11588/data/wzdkt6/7oeokhJanuary 2023

Fig2.xlsx

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.3 Dataset Index
10.11588/data/wzdkt6/ded50sJanuary 2023

Fig6.tab

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.3 Dataset Index
10.11588/data/wzdkt6/ojxopsJanuary 2023

Fig5.tab

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.3 Dataset Index
10.11588/data/wzdkt6/qancnkJanuary 2023

FigS11.tab

:unav

Authors

  • Gräter, Frauke ;
  • Franz, Florian ;
  • Winograd-Katz, Sabina ;
  • Tapia-Rojo, Rafael ;
  • Boujemaa-Paterski, Rajaa ;
  • Li, Wenhong ;
  • Unger, Tamar ;
  • Albeck, Shira ;
  • Aponte-Santamaria, Camilo ;
  • Garcia-Manyes, Sergi ;
  • Medalia, Ohad ;
  • Geiger, Benny
0 Citations0 Mentions15% FAIR0.3 Dataset Index
10.11588/data/wzdkt6/dsijp2January 2023