Automated Author Profile

Pedersen, Jannie

Current S-Index

1.3

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

0.7

Average Dataset Index per dataset

Total Datasets

2

Total datasets for this author

Average FAIR Score

84.6%

Average FAIR Score per dataset

Total Citations

2

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen

Despite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licenced for use in at risk populations. Here, we describe a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycoproteins and Ebola virus glycoprotein. Three heterologous immunizations successfully prevented infection by a different clade SHIV in 60% of non-human primates (NHPs). No trend was observed between resistance and antibody interactions. Resistance to infection was associated with high proportions of central memory T-cell CD69 and CD154 marker upregulation, increased IL-2 production, and a reduced IFN-γ response, offering insight into correlates of protection.

Authors

  • Kobinger, Gary P. ;
  • Jelinski, Joseph ;
  • Kowatsch, Monika M. ;
  • Lafrance, Marc-Alexandre ;
  • Berger, Alice ;
  • Pedersen, Jannie ;
  • Azizi, Hiva ;
  • Li, Yue ;
  • Scholte, Florine ;
  • Gomez, Alejandro ;
  • Hollett, Natasha ;
  • Le, Toby ;
  • Wade, Matthew ;
  • Fausther-Bovendo, Hugues ;
  • de La Vega, Marc-Antoine ;
  • Babuadze, George ;
  • XIII, Ara ;
  • Lamarre, Claude ;
  • Racine, Trina ;
  • Kang, Chil-Yong ;
  • Yao, Xiao-Jian ;
  • Alter, Galit ;
  • Arts, Eric ;
  • Fowke, Keith R.
1 Citation0 Mentions85% FAIR0.7 Dataset Index
10.6084/m9.figshare.240641382023

Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen

Despite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licenced for use in at risk populations. Here, we describe a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycoproteins and Ebola virus glycoprotein. Three heterologous immunizations successfully prevented infection by a different clade SHIV in 60% of non-human primates (NHPs). No trend was observed between resistance and antibody interactions. Resistance to infection was associated with high proportions of central memory T-cell CD69 and CD154 marker upregulation, increased IL-2 production, and a reduced IFN-γ response, offering insight into correlates of protection.

Authors

  • Jelinski, Joseph ;
  • Kowatsch, Monika M. ;
  • Lafrance, Marc-Alexandre ;
  • Berger, Alice ;
  • Pedersen, Jannie ;
  • Azizi, Hiva ;
  • Li, Yue ;
  • Scholte, Florine ;
  • Gomez, Alejandro ;
  • Hollett, Natasha ;
  • Le, Toby ;
  • Wade, Matthew ;
  • Fausther-Bovendo, Hugues ;
  • de La Vega, Marc-Antoine ;
  • Babuadze, George ;
  • XIII, Ara ;
  • Lamarre, Claude ;
  • Racine, Trina ;
  • Kang, Chil-Yong ;
  • Yao, Xiao-Jian ;
  • Alter, Galit ;
  • Arts, Eric ;
  • Fowke, Keith R. ;
  • Kobinger, Gary P.
1 Citation0 Mentions85% FAIR0.7 Dataset Index
10.6084/m9.figshare.24064138.v22023