Automated Author ProfileKaruzina, Irina
Naucno-issledovatel'skij institut biomedicinskoj himii imeni V N Orehovica
Karuzina, Irina
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 1.9 (sum of 2 datasets Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
Taking the cell proteomic response to different surfactants exposure as a base of our study, we assessed the eligibility of using human HaCaT keratinocytes culture as a test-system for studying the cytotoxicity of xenobiotics. As a models of toxicants, anionic surfactant and non-ionic surfactant were chosen. Overall, 21 proteins associated with cell detoxification and xenobiotics metabolism were detected, including orphan Cytochrome P450 2S1 (CYP2S1). According to the literature data, CYP2S1 induction in HaCaT was registered only by an increase in mRNA levels. The NextProt human proteome project database also did not contain information on the presence of CYP2S1 in keratinocytes at the protein level. The acquired data on quantitative and qualitative proteomics landscape change of HaCaT culture may be used for the revealing specific proteins/metabolic pathways related to the processes of metabolism of a wide spectrum of xenobiotics. Thus, the presented results draw a new prospect of using the HaCaT keratinocytes as a model of human epidermis for studying the metabolism of drugs/toxicants in human skin in vitro.
Authors
- Shkrigunov, Timur ;
- Vavilov, Nikita ;
- Samenkova, Natalia ;
- Kisrieva, Yulia ;
- Rusanov, Alexander ;
- Luzgina, Natalia ;
- Karuzina, Irina ;
- Lisitsa, Andrey ;
- Petushkova, Natalia
Taking the cell proteomic response to different surfactants exposure as a base of our study, we assessed the eligibility of using human HaCaT keratinocytes culture as a test-system for studying the cytotoxicity of xenobiotics. As a models of toxicants, anionic surfactant and non-ionic surfactant were chosen. Overall, 21 proteins associated with cell detoxification and xenobiotics metabolism were detected, including orphan Cytochrome P450 2S1 (CYP2S1). According to the literature data, CYP2S1 induction in HaCaT was registered only by an increase in mRNA levels. The NextProt human proteome project database also did not contain information on the presence of CYP2S1 in keratinocytes at the protein level. The acquired data on quantitative and qualitative proteomics landscape change of HaCaT culture may be used for the revealing specific proteins/metabolic pathways related to the processes of metabolism of a wide spectrum of xenobiotics. Thus, the presented results draw a new prospect of using the HaCaT keratinocytes as a model of human epidermis for studying the metabolism of drugs/toxicants in human skin in vitro.
Authors
- Shkrigunov, Timur ;
- Vavilov, Nikita ;
- Samenkova, Natalia ;
- Kisrieva, Yulia ;
- Rusanov, Alexander ;
- Luzgina, Natalia ;
- Karuzina, Irina ;
- Lisitsa, Andrey ;
- Petushkova, Natalia