Automated Author ProfileSayed, Samir
Children's Hospital of Philadelphia0000-0003-4981-5721
Sayed, Samir
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 2.0 (sum of 1 dataset Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre–a T cell receptor (pre-TCRa) expression. Low circulating naive ab T cell counts at birth persisted over time, with normal memory ab and high gd T cell counts. Their TCRa repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue ab T cell development. Only a minority of these individuals were sick, with infection, lymphoproliferation, and/or autoimmunity. We also report that 1 in 4000 individuals from the Middle East and South Asia are homozygous for a common hypomorphic PTCRA variant. They had normal circulating naive ab T cell counts but high gd T cell counts. Although residual pre-TCRa expression drove the differentiation of more ab T cells, autoimmune conditions were more frequent in these patients compared with the general population.
Authors
- Materna, Marie ;
- Delmonte, Ottavia ;
- Bosticardo, Marita ;
- Momenilandi, Mana ;
- Conrey, Peyton ;
- Charmeteau, Benedicte ;
- Bravetti, Clotilde ;
- Bellworthy, Rebecca ;
- Cederholm, Axel ;
- Staels, Frederik ;
- Ganoza, Christian A. ;
- Darko, Samuel ;
- Sayed, Samir ;
- Le Floc'h, Corentin ;
- Ogishi, Masato ;
- Rinchai, Darawan ;
- Guenoun, Andrea ;
- Bolze, Alexandre ;
- Khan, Taushif ;
- Gervais, Adrian ;
- Krüger, Renate ;
- Völler, Mirjam ;
- Palterer, Boaz ;
- Sadeghi-Shabestari, Mahnaz ;
- Langlois de Septenville, Anne ;
- Schramm, Chaim ;
- Shah, Sanjana ;
- Tello-Cajiao, John ;
- Pala, Francesca ;
- Amini, Kayla ;
- Campos, Jose S. ;
- Lima, Noemia ;
- Eriksson, Daniel ;
- Lévy, Romain ;
- Seeleuthner, Yoann ;
- Jyonouchi, Soma ;
- Ata, Manar ;
- Al Ali, Fatima ;
- Deswarte, Caroline ;
- Pereira, Anaïs ;
- Mégret, Jérôme Mégret ;
- Le Voyer, Tom ;
- Bastard, Paul Bastard ;
- Berteloot, Laureline ;
- Dussiot, Michael ;
- Vladikine, Natasha ;
- Cardenas, Paula P. ;
- Jouanguy, Emmanuelle ;
- Al-Qahtani, Mashael ;
- Hasan, Amal ;
- Thanaraj, Thangavel Alphonse ;
- Rosain, Jérémie ;
- Al Qureshah, Fahd ;
- Sabato, Vito ;
- Alyanakian, Marie-Alexandra ;
- Leruez-Ville, Marianne ;
- Rozenberg, Flore ;
- Haddad, Elie ;
- Regueiro, Jose ;
- Toribio, María L. ;
- Kelsen, Judith R. ;
- Salehi, Mansoor ;
- Nasiri, Shahram ;
- Torabizadeh, Mehdi ;
- Rokni-Zadeh, Hassan ;
- Changi-Ashtiani, Majid ;
- Vatandoost, Nasimeh ;
- Moravej, Hossein ;
- Akrami, Seyed Mohammad ;
- Mazloomrezaei, Mohsen ;
- Cobat, Aurélie ;
- Meyts, Isabelle ;
- Etsushi, Toyofuku ;
- Nishimura, Madoka ;
- Moriya, Kunihiko ;
- Mizukami, Tomoyuki ;
- Imai, Kohsuke ;
- Abel, Laurent ;
- Malissen, Bernard ;
- Al-Mulla, Fahd ;
- Alkuraya, Fowzan ;
- Parvaneh, Nima ;
- von Bernuth, Horst ;
- Beetz, Christian ;
- Davi, Frédéric ;
- Douek, Daniel C. ;
- Cheynier, Remi ;
- Langlais, David ;
- Landegren, Nils ;
- Marr, Nico ;
- Morio, Tomohiro ;
- Shahrooei, Mohammad ;
- Schrijvers, Rik ;
- Henrickson, Sarah ;
- Luche, Hervé ;
- Notarangelo, Luigi ;
- Casanova, Jean-Laurent ;
- Beziat, Vivien