Automated Author Profile

Jiajun Yan

McMaster University, Hamilton, Ontario, Canada

Current S-Index

0.3

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

0.3

Average Dataset Index per dataset

Total Datasets

1

Total datasets for this author

Average FAIR Score

30.8%

Average FAIR Score per dataset

Total Citations

0

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Statistical Methods for Analyzing EuroQol 5 Dimension 5 (EQ-5D) in Randomized Clinical Trials

The EQ-5D (EuroQol five-dimensions) questionnaire is a patient-reported outcome that measures individual’s health-related quality of life (HRQoL) from 5 dimensions, including mobility (MO), self-care (SC), usual activities (UA), pain/discomfort (PD), and anxiety/depression (AD). The original version EQ-5D has three response options indicating no, some, and extreme problems in each of the five dimensions (the EQ-5D-3L (EuroQol five-dimension three-level)), which were later expanded into 5 levels: no, slight, moderate, severe, and extreme problems (the EQ-5D-5L (EuroQol five-dimension five-level)). The EQ-5D questionnaire has been widely collected in randomized clinical trials (RCTs) and extensively used in economic evaluation for reimbursement decision across various disease areas. However, using EQ-5D to evaluate treatment efficacy on HRQoL is rather limited, partially due to the lack of methodological guideline. There are guidelines on analyzing and reporting EQ-5D data, but these mostly focus on non-controlled studies where EQ-5D data is only collected once. However, in RCTs, with the aim of testing the effect of the treatment , EQ-5D data are usually collected at multiple timepoints during the trial. Our recent research shows that there are significant variations in the statistical methods that have been used to analyze EQ-5D data in the RCTs. Through access to published RCTs where the EQ-5D was collected, we plan to apply and compare commonly used methods and new methods to analyze the EQ-5D data across a wide range of disease areas and trial designs. We will examine model assumptions, evaluate model performance/goodness of fit, and compare model results in each trial analysis.This project will produce empirical (observed) evidence in comparing statistical models for estimating treatment effect on the EQ-5D. Furthermore, the output from this research program can be used to develop practical guidance on analyzing the EQ-5D in the RCT setting. Such guidance can potentially increase awareness and usage of EQ-5D to assess treatment effect on patients’ HRQoL.

Authors

  • Jiajun Yan
0 Citations0 Mentions31% FAIR0.3 Dataset Index
10.25934/pr00009253January 2024