Automated Author ProfilePhillips, Ildiko
Phillips, Ildiko
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 0.8 (sum of 2 datasets Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimic viral-like responses with implications on tumor cell state and the response of the surrounding microenvironment. To better understand the relationship of repeat RNAs in human PDAC, we performed spatial molecular imaging at single cell resolution in 46 primary tumors revealing correlations of high repeat RNA expression with alterations in epithelial state in PDAC cells and myofibroblast phenotype in cancer-associated fibroblasts (CAFs). This loss of cellular identity is observed with dosing of extracellular vesicles (EVs) and individual repeat RNAs of PDAC and CAF cell culture models pointing to cell-cell intercommunication of these viral-like elements. Differences in PDAC and CAF response are driven through distinct innate immune signaling through interferon regulatory transcription factor 3 (IRF3). The cell context specific viral-like responses to repeat RNAs provides a mechanism for modulation of cellular plasticity in diverse cell types in the PDAC microenvironment.
Authors
- You, Eunae ;
- Danaher, Patrick ;
- Lu, Chenyue ;
- Sun, Siyu ;
- Zou, Luli ;
- Phillips, Ildiko ;
- Rojas, Alexandra ;
- Ho, Natalie ;
- Song, Yuhui ;
- Raabe, Michael ;
- Xu, Katherine ;
- Richieri, Peter ;
- Li, Hao ;
- Aston, Natalie ;
- Porter, Rebecca ;
- Patel, Bidish ;
- Nieman, Linda ;
- Schurman, Nathan ;
- Hudson, Briana ;
- North, Khrystyna ;
- Church, Sarah ;
- Deshpande, Vikram ;
- Liss, Andrew ;
- Kim, Tae ;
- Cui, Yi ;
- Kim, Youngmi ;
- Greenbaum, Benjamin ;
- Aryee, Martin ;
- Ting, David
Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimic viral-like responses with implications on tumor cell state and the response of the surrounding microenvironment. To better understand the relationship of repeat RNAs in human PDAC, we performed spatial molecular imaging at single cell resolution in 46 primary tumors revealing correlations of high repeat RNA expression with alterations in epithelial state in PDAC cells and myofibroblast phenotype in cancer-associated fibroblasts (CAFs). This loss of cellular identity is observed with dosing of extracellular vesicles (EVs) and individual repeat RNAs of PDAC and CAF cell culture models pointing to cell-cell intercommunication of these viral-like elements. Differences in PDAC and CAF response are driven through distinct innate immune signaling through interferon regulatory transcription factor 3 (IRF3). The cell context specific viral-like responses to repeat RNAs provides a mechanism for modulation of cellular plasticity in diverse cell types in the PDAC microenvironment.
Authors
- You, Eunae ;
- Danaher, Patrick ;
- Lu, Chenyue ;
- Sun, Siyu ;
- Zou, Luli ;
- Phillips, Ildiko ;
- Rojas, Alexandra ;
- Ho, Natalie ;
- Song, Yuhui ;
- Raabe, Michael ;
- Xu, Katherine ;
- Richieri, Peter ;
- Li, Hao ;
- Aston, Natalie ;
- Porter, Rebecca ;
- Patel, Bidish ;
- Nieman, Linda ;
- Schurman, Nathan ;
- Hudson, Briana ;
- North, Khrystyna ;
- Church, Sarah ;
- Deshpande, Vikram ;
- Liss, Andrew ;
- Kim, Tae ;
- Cui, Yi ;
- Kim, Youngmi ;
- Greenbaum, Benjamin ;
- Aryee, Martin ;
- Ting, David