Automated Author ProfileKoudelka, Tomas
Kiel University
Koudelka, Tomas
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 2.3 (sum of 1 dataset Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
For the semi-automated identification of potential cleavage specificity-modulating SNVs we developed a program, called CAIRA (Catalytic Associated Irregular Residue Analyser). Entering the UniProt ID of a protease, CAIRA takes the predicted AlphaFold structure, generates a user-definable radius (e.g. 20 Å) around the active site and filters the COSMIC database for cancer-associated SNVs within this radius, which might have cleavage specificity-modulating effects. CAIRA can be used with all types of proteases (metallo, serine, aspartyl and cysteine proteases). To further assess their potential impact, SNV-affected amino acids are labelled in the protein structure of a downloadable pdb-file.
Authors
- Becker-Pauly, Christoph ;
- David, Nele ;
- Koudelka, Tomas ;
- Joos, Corentin ;
- Scharfenberg, Franka ;
- Rüffer, Malina ;
- Armbrust, Fred ;
- Georgiadis, Dimitris ;
- Beau, Fabrice ;
- Stahmer, Lea ;
- Rahn, Sascha ;
- Tholey, Andreas ;
- Pietrzik, Claus ;
- Bickenbach, Kira