Automated Author Profile
Clarke, Sandra
Agriculture and Agri-Food Canada
0000-0003-0919-5652

Current S-Index

3.5

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

1.8

Average Dataset Index per dataset

Total Datasets

Total datasets for this author

Average FAIR Score

82.7%

Average FAIR Score per dataset

Total Citations

Total citations to the author's datasets

Total Mentions

Total mentions of the author's datasets

S-Index Interpretation

The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.

What it means:

A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
It provides a single number to track your research data impact over time

Current S-Index: 3.5 (sum of 2 datasets Dataset Index scores)

More information here.

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting (Version: 5)

The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled the release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease. Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy.

Authors

Ma, Wei Jen ;
Wang, Changqing ;
Kothandapani, Jagatheeswaran ;
Luzentales-Simpson, Matthew ;
Menzies, Susan ;
Bescucci, Danisa ;
Lange, Máximo ;
Fraser, Alexander ;
Gusse, Jenny ;
House, Kathaleen ;
Moote, Paul ;
Xing, Xiaohui ;
Grondin, Julie ;
Hui, Benjamin Wei Qiang ;
Clarke, Sandra ;
Shelton, Tara ;
Haskey, Natasha ;
Gibson, Deanna ;
Martens, Eric ;
Abbott, Wade ;
Inglis, G. Douglas ;
Sly, Laura ;
Brumer, Harry

1 Citation0 Mentions77% FAIR2.2 Dataset Index

10.5061/dryad.np5hqc04qMarch 2025

Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting (Version: 1.0)

Abstract The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled the release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease. Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy.