Automated Author Profile

Costa-Mattioli, Mauro

Baylor College of Medicine
0000-0002-9809-4732

Current S-Index

0.0

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

0.0

Average Dataset Index per dataset

Total Datasets

1

Total datasets for this author

Average FAIR Score

73.1%

Average FAIR Score per dataset

Total Citations

0

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Effect of integrated stress response inhibitor (ISRIB) on eIF2a response and hippocampal-dependent behavioral outcomes in controlled cortical impact and closed head injury TBI male mouse models (Version: 1.0)

STUDY PURPOSE: The purpose of the study was to investigate the potential therapeutic effect of inhibiting the integrated stress response with ISRIB (integrated stress response inhibitor) at chronic timepoints after traumatic brain injury. DATA COLLECTED: The dataset includes several experiments with 152 male C57BL/6J (RRID:IMSR_JAX:000664) mice using the parietal controlled cortical impact (CCI) or Closed Head Injury (CHI) TBI models. A summary of experiments is as follows: (1) Ratio of phosphorylated eIF2a to total eIF2a protein levels between Sham and TBI animals as quantified by quantitative western blot analysis at acute (1 days post injury; dpi) and chronic (26-28 dpi) timepoints. (2) Performance of Sham and CCI animals treated with Vehicle or ISRIB (2.5mg/kg ISRIB) on radial arm water maze (errors; RAWM). Treatment was given starting on the day prior to behavior and after the final trial of each day of behavior. (3) Performance of Sham and CHI animals treated with Vehicle or ISRIB (2.5mg/kg ISRIB) on delayed-matching-to-place Barnes maze (time to escape; DMP). Treatment was given starting on the day prior to behavior and after the final trial of each day of behavior. DATA USAGE NOTES:

Authors

  • Chou, Austin ;
  • Krukowski, Karen ;
  • Jopson, Timothy ;
  • Zhu, Ping Jun ;
  • Costa-Mattioli, Mauro ;
  • Walter, Peter ;
  • Rosi, Susanna
0 Citations0 Mentions73% FAIR0.4 Dataset Index
10.34945/f53g6m2026