This is an accompanying data set to a paper which will contain all the required information a reader would need. The abstract for the paper is: Our previous work has established that micron resolution photolithography can be employed to make microsquare nanoband edge electrode (MNEE) arrays. The MNEE configuration enables systematic control of the parameters (electrode number, cavity array spacing, and nanoelectrode dimensions and placement) which control geometry, conferring consistent high-fidelity electrode response across the array (e.g. high signal, high signal-to-noise, low limits of detection and fast, steady-state, reproducible and quantitative response) and allowing the tuning of individual and combined electrode interactions. Building on this, in this paper we now produce and characterise a Micropore Nanoband Electrode (MNE) Array designed for flow-through detection, where an MNEE edge electrode configuration is used to form a nanotube electrode embedded in the wall of each micropore, formed as an array of pores of controlled pore size and placement through an insulating membrane of sub-micrometer thickness. The success of this approach is established by the close correspondence between experiment and simulation and the enhanced and quantitative detection of redox species flowing through the micropores over the very wide range of flow rates relevant e.g. to (bio)sensing and chromatography. Quantitative electrochemical reaction with low conversion, suitable for analysis, is demonstrated at high flow, whilst quantitative electrochemical reaction with high conversion, suitable for electrochemical product generation, is enabled at lower flow. The fundamental array response is analysed in terms of established flow theories, demonstrating the additive contributions of within pore enhanced diffusional (nanoband edge) and advective (Levich-type) currents, the control of the degree of diffusional overlap between pores through pore spacing and flow rate, the control by design across length scales ranging from nanometer through micrometer to a centimetre array and the ready determination of physicochemical parameters, enabling discussion of the potential of this breakthrough technology to addresses unmet needs in generation and analysis.

Dataset for "Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor" by Marland et al. (2020) https://doi.org/10.1016/j.sbsr.2020.100375. # Change to title # The original title of this dataset was: 'Dataset for "An implantable microfabricated sensor for real-time measurement of tissue oxygenation"' reflecting the title of the original associated manuscript. The manuscript title changed as a result of the publication process. On 6 November 2020 the title of the dataset was subsequently changed to match the title of the associated journal article, to become 'Dataset for "Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor"'.

Data associated with the manuscript: "Miniaturisation of a peptide-based electrochemical protease activity sensor using platinum microelectrodes". Robust and sensitive miniaturised peptide-based electrochemical biosensor for protease activity detection was developed using platinum microelectrodes. Significant differences were observed between the responses of the Pt macroelectrode and microelectrode systems indicative of increased reproducibility in the microelectrode SAM structure and sensor performance between the electrodes, increased storage stability and a decrease in the cleavage rate at functionalised microelectrodes, which is mitigated by measurement at normal body temperature. This dataset contains the data used for the created figures included in the manuscript.

Data associated to manuscript. Includes set of tables containing the data used for obtaining figures and results.

Dataset corresponding to manuscript entitled "Electrodrugs: an electrochemical prodrug activation strategy".

These data are all the data from the graphical Figures in the paper "Functionalised Microscale Nanoband Edge Electrode (MNEE) Arrays; the systematic quantitative study of hydrogels grown on nanoelectrode biosensor arrays for enhanced sensing in biological media", Authors: Andrew Piper, Ben M. Alston, Dave J. Adams and Andrew R. Mount. [ARTICLE ABSTRACT] Nanoelectrodes and nanoelectrode arrays show enhanced diffusion and greater Faradaic current densities and signal-to-noise ratios than macro and microelectrodes, which can lead to enhanced sensing and detection. One example is the microsquare nanoband edge electrode (MNEE) array system, readily formed through microfabrication and whose quantitative response has been established electroanalytically. Hydrogels have been shown to have applications in drug delivery, tissue engineering, and anti-biofouling; some also have the ability to be grown electrochemically. Here, we combine these two emerging technologies to demonstrate the principles of a hydrogel-coated nanoelectrode array biosensor that is resistant to biofouling. We first electrochemically grow and analyze hydrogels on MNEE arrays. The structure of these gels is shown by imaging to be electrochemically controllable, reproducible and structurally hierarchical. This structure is determined by the MNEE array diffusion fields, consistent with the established hydrogel formation reaction, and varies in structural scale from nano (early time, near electrode growth) to micro (for isolated elements in the array) to macro (when there is array overlap) with distance from the electrode, forming a hydrogel mesh of increasing density on progression from solution to electrode. There is also increased hydrogel structural density observed at electrode corners, attributable to enhanced diffusion. The resulting hydrogel structure can be formed on (and is firmly anchored to/through) an established clinically relevant biosensing layer without compromising detection. It is also shown to be capable, through proof-of-principal model protein studies using Bovine serum albumin (BSA), of preventing protein biofouling whilst enabling smaller molecules such as DNA to pass through the hydrogel matrix and be sensed. Together, this demonstrates a method for developing reproducible, quantitative electrochemical nanoelectrode biosensors able to sense selectively in real-world sample matrices through the tuning of their interfacial properties.

Data associated with the manuscript. "Electrochemical sensing of human neutrophil elastase and polymorphonuclear neutrophil activity". Design and evaluation of a peptide-based electrochemical biosensor for HNE activity detection. The analytical characteristics of the sensor were evaluated. The platform was applied for the detection of HNE in real blood samples. Dataset includes set of tables containing the data used for obtaining figures and results.

This data set contains the raw data for Figures 6 and 7, as well as Table 1 presented in the paper ‘A three-electrode Electrochemical Liquid to Electrode (LtE) Cell for Rapid and Flexible Measurements of Small Sample Sizes’. This publication will be open access.

This dataset is a companion to the paper, "Improving the Yield and Lifetime of Microfabricated Sensors for Harsh Environments". This details several methods of increasing the robustness of microfabricated microelectrodes for use in the molten salt LKE at 450 degrees Celsius. The dataset includes: (a) Yield statistics for two different microelectrode layouts (IML and RCA), which comprise the number of working and failed electrodes for each design. (b) Measurements to determine the lifetime of the IML and RCA electrodes. These measurements were of the reduction and oxidation of AgCl. The measurements were made consecutively until the device failed, and each is stored as a separate text file of applied potential vs measured current. (c) Experiments performed using test structures, where the potential was held steady and the current monitored for 15 minutes. Each set of measurements are stored as a .csv file, which contains three experiments per size of test structure for four test structures.

Molten salt is a corrosive, high temperature environment which is extremely challenging for sensing technology. Microelectrodes are well-positioned as electrochemical sensors and previous work has delivered electrodes capable of operating in such conditions. However, the lifetime of these sensors requires improvement. This work investigates the origins of device failure.