Automated Author ProfileMiao, Xiaoping
Huazhong University of Science and Technology
Miao, Xiaoping
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 2.2 (sum of 1 dataset Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
Genome-wide association studies (GWAS) have identified multiple susceptibility loci for colorectal cancer, but much of heritability remains unexplained. To identify additional susceptibility loci for colorectal cancer, here we perform a GWAS in 1,023 cases and 1,306 controls and replicate the findings in seven independent samples from China, comprising 5,317 cases and 6,887 controls. We find a variant at 12p13.2 associated with colorectal cancer risk (rs2238126 in ETV6, P = 2.67 × 10-10). We replicate this association in an additional 1,046 cases and 1,076 controls of European ancestry (P = 0.034). The G allele of rs2238126 confers earlier age at onset of colorectal cancer (P = 1.98 × 10-6) and reduces the binding affinity of transcriptional enhancer MAX. The mRNA level of ETV6 is significantly lower in colorectal tumors than in paired normal tissues. Our findings highlight the potential importance of genetic variation in ETV6 conferring susceptibility to colorectal cancer.
Authors
- Wang, Meilin ;
- Gu, Dongying ;
- Du, Mulong ;
- Xu, Zhi ;
- Zhang, Suzhan ;
- Zhu, Lingjun ;
- Lu, Jiachun ;
- Zhang, Rui ;
- Xing, Jinliang ;
- Miao, Xiaoping ;
- Chu, Haiyan ;
- Hu, Zhibin ;
- Yang, Lei ;
- Tang, Cuiju ;
- Pan, Lei ;
- Du, Haina ;
- Zhao, Jian ;
- Du, Jiangbo ;
- Tong, Na ;
- Sun, Jielin ;
- Shen, Hongbing ;
- Xu, Jianfeng ;
- Zhang, Zhengdong ;
- Chen, Jinfei