Automated Author Profile

Kalimuthu Kalishwaralal

Current S-Index

4.2

Sum of Dataset Indices for all datasets

Average Dataset Index per Dataset

2.1

Average Dataset Index per dataset

Total Datasets

2

Total datasets for this author

Average FAIR Score

84.6%

Average FAIR Score per dataset

Total Citations

0

Total citations to the author's datasets

Total Mentions

0

Total mentions of the author's datasets

S-Index Interpretation

S-Index Over Time

Cumulative Citations Over Time

Cumulative Mentions Over Time

Datasets

Comparative analysis of cardiovascular effects of selenium nanoparticles and sodium selenite in zebrafish embryos

Selenium acts as an important element in the prevention and treatment of cardiovascular diseases but their health-related effects have not been fully explored. As a novel attempt, zebrafish embryos were treated separately with SeNPs (5–25 μg/ml) and sodium selenite (5–25 μg/ml) starting at early blastula stage. Abnormalities were also observed in the morphology of the zebrafish embryos. The SeNPs-treated embryos exhibited concentration-dependent increased in mortality, pericardial edema, and cardiac arrhythmia. In contrast, sodium selenite showed no significant malformation effect in developing zebrafish embryos. The results of the present study conclude that the SeNPs were more toxic than sodium selenite. The results also suggest that lower concentrations of SeNPs and sodium selenite can be used as possible therapeutic agents for cardiovascular-related problems.

Authors

  • Kalimuthu Kalishwaralal ;
  • Subhaschandrabose Jeyabharathi ;
  • Sundar, Krishnan ;
  • Azhaguchamy Muthukumaran
0 Citations0 Mentions85% FAIR2.1 Dataset Index
10.6084/m9.figshare.3309430January 2016

Comparative analysis of cardiovascular effects of selenium nanoparticles and sodium selenite in zebrafish embryos

Selenium acts as an important element in the prevention and treatment of cardiovascular diseases but their health-related effects have not been fully explored. As a novel attempt, zebrafish embryos were treated separately with SeNPs (5–25 μg/ml) and sodium selenite (5–25 μg/ml) starting at early blastula stage. Abnormalities were also observed in the morphology of the zebrafish embryos. The SeNPs-treated embryos exhibited concentration-dependent increased in mortality, pericardial edema, and cardiac arrhythmia. In contrast, sodium selenite showed no significant malformation effect in developing zebrafish embryos. The results of the present study conclude that the SeNPs were more toxic than sodium selenite. The results also suggest that lower concentrations of SeNPs and sodium selenite can be used as possible therapeutic agents for cardiovascular-related problems.

Authors

  • Kalimuthu Kalishwaralal ;
  • Subhaschandrabose Jeyabharathi ;
  • Sundar, Krishnan ;
  • Azhaguchamy Muthukumaran
0 Citations0 Mentions85% FAIR2.1 Dataset Index
10.6084/m9.figshare.3309430.v1January 2016