Automated Author ProfileKanduri, Meena
Kanduri, Meena
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 17.6 (sum of 27 datasets Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
EZH2 is overexpressed in poor-prognostic chronic lymphocytic leukaemia (CLL) cases, acting as an oncogene; however, thus far, the EZH2 target genes in CLL have not been disclosed. In this study, using ChIP-sequencing, we identified EZH2 and H3K27me3 target genes in two prognostic subgroups of CLL with distinct prognosis and outcome, i.e., cases with unmutated (U-CLL, n = 6) or mutated IGHV genes (M-CLL, n = 6). While the majority of oncogenic pathways were equally enriched for EZH2 target genes in both prognostic subgroups, PI3K pathway genes were differentially bound by EZH2 in U-CLL versus M-CLL. The occupancy of EZH2 for selected PI3K pathway target genes was validated in additional CLL samples (n = 16) and CLL cell lines using siRNA-mediated EZH2 downregulation and ChIP assays. Intriguingly, we found that EZH2 directly binds to the IGF1R promoter along with MYC and upregulates IGF1R expression in U-CLL, leading to downstream PI3K activation. By investigating an independent CLL cohort (n = 96), a positive correlation was observed between EZH2 and IGF1R expression with higher levels in U-CLL compared to M-CLL. Accordingly, siRNA-mediated downregulation of either EZH2, MYC or IGF1R and treatment with EZH2 and MYC pharmacological inhibitors in the HG3 CLL cell line induced a significant reduction in PI3K pathway activation. In conclusion, we characterize for the first time EZH2 target genes in CLL revealing a hitherto unknown implication of EZH2 in modulating the PI3K pathway in a non-canonical, PRC2-independent way, with potential therapeutic implications considering that PI3K inhibitors are effective therapeutic agents for CLL.
Authors
- Subazini Thankaswamy Kosalai ;
- Morsy, Mohammad Hamdy Abdelrazak ;
- Papakonstantinou, Nikos ;
- Mansouri, Larry ;
- Stavroyianni, Niki ;
- Chandrasekhar Kanduri ;
- Stamatopoulos, Kostas ;
- Rosenquist, Richard ;
- Kanduri, Meena
Additional file 3. List of common, hyper and hypo DhMRS between CLL samples and normal controls comparisons
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 4. List of common, hyper and hypo DMRS between CLL samples and normal controls comparisons
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 4. List of common, hyper and hypo DMRS between CLL samples and normal controls comparisons
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 3. List of common, hyper and hypo DhMRS between CLL samples and normal controls comparisons
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 5. List of common, hyper and hypo DEGS between CLL samples and normal controls comparisons
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 5. List of common, hyper and hypo DEGS between CLL samples and normal controls comparisons
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 6. List of REACTOME and GO Biological pathways from DhMRs obtained between CLL samples and normal controls comparisons and list of CLL active and super enhancers based on H3K27Ac ChIP seq data
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 7. Mass spectrometry data and list of primer sequences used in this study
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena
Additional file 7. Mass spectrometry data and list of primer sequences used in this study
Authors
- Wernig-Zorc, Sara ;
- Yadav, Mukesh ;
- Kopparapu, Pradeep ;
- Bemark, Mats ;
- Hallgerdur Kristjansdottir ;
- Per-Ola Andersson ;
- Chandrasekhar Kanduri ;
- Kanduri, Meena