Automated Author ProfileJaddoe, Vincent W. V.
Jaddoe, Vincent W. V.
Current S-Index
Sum of Dataset Indices for all datasets
Average Dataset Index per Dataset
Average Dataset Index per dataset
Total Datasets
Total datasets for this author
Average FAIR Score
Average FAIR Score per dataset
Total Citations
Total citations to the author's datasets
Total Mentions
Total mentions of the author's datasets
S-Index Interpretation
The S-Index (Sharing Index) is a comprehensive metric that represents the cumulative impact of all your datasets. It is calculated as the sum of Dataset Index scores across all your claimed datasets.
What it means:
- A higher S-index indicates greater overall impact of your datasets relative to typical datasets in their fields of research
- The S-Index grows as you add more datasets or as existing datasets gain more citations and mentions
- It provides a single number to track your research data impact over time
Current S-Index: 5.0 (sum of 12 datasets Dataset Index scores)
More information here.
S-Index Over Time
Cumulative Citations Over Time
Cumulative Mentions Over Time
Datasets
Maternal glycemic dysregulation during pregnancy increases the risk of adverse health outcomes in her offspring, a risk thought to be linearly related to maternal hyperglycemia. It is hypothesized that changes in offspring DNA methylation (DNAm) underline these associations. To address this hypothesis, we conducted fixed-effects meta-analyses of epigenome-wide association study (EWAS) results from eight birth cohorts investigating relationships between cord blood DNAm and fetal exposure to maternal glucose (Nmaximum= 3,503), insulin (Nmaximum= 2,062), and area under the curve of glucose (AUCgluc) following oral glucose tolerance tests (Nmaximum = 1,505). Inflation and bias was addressed with the bacon Bioconductor package for individual cohorts and the meta-analysis results and reported model estimates and standard errors are adjusted. Greater maternal AUCgluc during pregnancy was associated with lower cord blood DNAm at neighboring CpGs cg26974062 and cg02988288 in TXNIP. Follow-up analyses show that these changes may have functional and later-life consequences and warrant further mediation and causal analysis. The corresponding paper can be found here: https://doi.org/10.2337/dc21-1701. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a Zenodo DOI generated for you go to ewascatalog.org/upload.
Authors
- Tobi, Elmar W. ;
- Juvinao-Quintero, Diana L. ;
- Justiina Ronkainen ;
- Ott, Raffael ;
- Alfano, Rossella ;
- Canouil, Mickaël ;
- Geurtsen, Madelon L. ;
- Amna Khamis ;
- Küpers, Leanne K. ;
- Lim, Ives Y. ;
- Perron, Patrice ;
- Pesce, Giancarlo ;
- Tuhkanen, Johanna ;
- Starling, Anne P. ;
- Andrew, Toby ;
- Binder, Elisabeth ;
- Caiazzo, Robert ;
- Chan, Jerry K. Y. ;
- Gaillard, Romy ;
- Gluckman, Peter D. ;
- Keikkala, Elina ;
- Karnani, Neerja ;
- Mustaniemi, Sanna ;
- Nawrot, Tim S. ;
- Pattou, François ;
- Plusquin, Michelle ;
- Raverdy, Violeta ;
- Tan, Kok Hian ;
- Tzala, Evangelia ;
- Raikkonen, Katri ;
- Winkler, Christiane ;
- Anette-G. Ziegler ;
- Annesi-Maesano, Isabella ;
- Bouchard, Luigi ;
- Yap Seng Chong ;
- Dabelea, Dana ;
- Felix, Janine F. ;
- Heude, Barbara ;
- Jaddoe, Vincent W. V. ;
- Lahti, Jari ;
- Reimann, Brigitte ;
- Vääräsmäki, Marja ;
- Bonnefond, Amélie ;
- Froguel, Philippe ;
- Hummel, Sandra ;
- Kajantie, Eero ;
- Marjo-Riita Jarvelin ;
- Steegers-Theunissen, Regine P.M. ;
- Howe, Caitlin G. ;
- M.F. Hivert ;
- Sebert, Sylvain
Maternal glycemic dysregulation during pregnancy increases the risk of adverse health outcomes in her offspring, a risk thought to be linearly related to maternal hyperglycemia. It is hypothesized that changes in offspring DNA methylation (DNAm) underline these associations. To address this hypothesis, we conducted fixed-effects meta-analyses of epigenome-wide association study (EWAS) results from eight birth cohorts investigating relationships between cord blood DNAm and fetal exposure to maternal glucose (Nmaximum= 3,503), insulin (Nmaximum= 2,062), and area under the curve of glucose (AUCgluc) following oral glucose tolerance tests (Nmaximum = 1,505). Inflation and bias was addressed with the bacon Bioconductor package for individual cohorts and the meta-analysis results and reported model estimates and standard errors are adjusted. Greater maternal AUCgluc during pregnancy was associated with lower cord blood DNAm at neighboring CpGs cg26974062 and cg02988288 in TXNIP. Follow-up analyses show that these changes may have functional and later-life consequences and warrant further mediation and causal analysis. The corresponding paper can be found here: https://doi.org/10.2337/dc21-1701. Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a Zenodo DOI generated for you go to ewascatalog.org/upload.
Authors
- Tobi, Elmar W. ;
- Juvinao-Quintero, Diana L. ;
- Justiina Ronkainen ;
- Ott, Raffael ;
- Alfano, Rossella ;
- Canouil, Mickaël ;
- Geurtsen, Madelon L. ;
- Amna Khamis ;
- Küpers, Leanne K. ;
- Lim, Ives Y. ;
- Perron, Patrice ;
- Pesce, Giancarlo ;
- Tuhkanen, Johanna ;
- Starling, Anne P. ;
- Andrew, Toby ;
- Binder, Elisabeth ;
- Caiazzo, Robert ;
- Chan, Jerry K. Y. ;
- Gaillard, Romy ;
- Gluckman, Peter D. ;
- Keikkala, Elina ;
- Karnani, Neerja ;
- Mustaniemi, Sanna ;
- Nawrot, Tim S. ;
- Pattou, François ;
- Plusquin, Michelle ;
- Raverdy, Violeta ;
- Tan, Kok Hian ;
- Tzala, Evangelia ;
- Raikkonen, Katri ;
- Winkler, Christiane ;
- Anette-G. Ziegler ;
- Annesi-Maesano, Isabella ;
- Bouchard, Luigi ;
- Yap Seng Chong ;
- Dabelea, Dana ;
- Felix, Janine F. ;
- Heude, Barbara ;
- Jaddoe, Vincent W. V. ;
- Lahti, Jari ;
- Reimann, Brigitte ;
- Vääräsmäki, Marja ;
- Bonnefond, Amélie ;
- Froguel, Philippe ;
- Hummel, Sandra ;
- Kajantie, Eero ;
- Marjo-Riita Jarvelin ;
- Steegers-Theunissen, Regine P.M. ;
- Howe, Caitlin G. ;
- M.F. Hivert ;
- Sebert, Sylvain
Additional file 10: Table S11. Look-up results of adult type 2 diabetes associated CpGs in maternal early-pregnancy glucose EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.
Additional file 11: Table S12. Look-up results of adult type 2 diabetes associated CpGs in maternal early-pregnancy insulin EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.
Additional file 11: Table S12. Look-up results of adult type 2 diabetes associated CpGs in maternal early-pregnancy insulin EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.
Additional file 8: Table S9. Look-up results of maternal glucose metabolism associated CpGs in maternal early-pregnancy glucose EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.
Additional file 9: Table S10. Look-up results of maternal glucose metabolism associated CpGs in maternal early-pregnancy insulin EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.
Additional file 9: Table S10. Look-up results of maternal glucose metabolism associated CpGs in maternal early-pregnancy insulin EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.
Additional file 8: Table S9. Look-up results of maternal glucose metabolism associated CpGs in maternal early-pregnancy glucose EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.
Additional file 10: Table S11. Look-up results of adult type 2 diabetes associated CpGs in maternal early-pregnancy glucose EWAS results.
Authors
- Geurtsen, Madelon L. ;
- Jaddoe, Vincent W. V. ;
- Gaillard, Romy ;
- Felix, Janine F.