An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter-γ-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene

An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitrilesvia a cascade Stetter-γ-ketonitrile ­cyclizationreaction of aromatic aldehydes with acylidenemalono­nitriles,catalyzed by N-heterocyclic carbenes, has been developed. This procedureprovides the corresponding products in moderate to high yields undermild conditions.