Supporting data for The Functional Roles of SCD1/FADS2 Lipid Desaturases in Modulating Lipid Metabolic Activities and Redox-driven Ferroptosis in Ascites-derived Ovarian Cancer Cells
Xuan, Yang
Description
- The desaturation abilities of SCD1/FADS2 are aberrantly augmented in ascites-derived ovarian cancer cells.2. SCD1/FADS2 causes the elevation of poly- and mono-unsaturated fatty acids (UFAs) and enhanced oncogenic properties of ovarian cancer cells.3. SCD1/FADS2 modulates GSH/GSSG ratio and GPX4, preventing induction of ferroptosis.4.Targeting suppression of SCD1/FADS2 synergistically enhances cisplatin-mediated cytotoxicity in ascites-derived ovarian cancer cells.
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Publication Details
DOI
Publisher
University of Hong Kong
Subfield
Oncology
Field
Medicine
Domain
Health Sciences
Confidence Score
58%
Source
Scholar Data Model
Keywords
111402 Obstetrics and GynaecologyFOS: Clinical medicine111299 Oncology and Carcinogenesis not elsewhere classified111201 Cancer Cell Biology111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)