IMPC

Abstract(s): The International Mouse Phenotypic Consortium (IMPC) is an international effort by 21 research institutions to identify the function of every protein-coding gene in the mouse genome. To achieve this, the IMPC is systematically switching off or ‘knocking out’ each of the roughly 20,000 genes that make up the mouse genome. Subsequently, the knock out mice undergo standardised physiological tests (phenotyping tests) across a range of biological systems in order to infer gene function. The overall aim of the project is not only to develop insight into the function of every gene, but also to provide transformative insights into the genetic basis of disease that will impact upon clinical diagnosis and management and ultimately prevent, detect, diagnose and treat disease. This published dataset is based on hundreds of E15.5 and E18.5 mouse models, all of which are homozygous knockouts, excluding the wildtype littermates.