Peripheral T-cell profiling reveals downregulated exhaustion marker and increased diversity in lymphedema post-lymphatic venous anastomosis

In this study, we compared T cell receptor (TCR) repertoire diversity between patients with lymphedema, post-lymphatic venous anastomosis and healthy controls (HCs). TCR diversity was decreased in lymphedema compared with HCs; such TCR skewing was drastically improved in post-LVA.