Single-cell multimodal sequencing data from: Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases

This dataset contains single-cell multimodal data (scRNA-, scBCR-, and scADT-seq) for twenty-three cases of childhood BCP-ALL, including four samples each of BCR::ABL1-positive, ETV6::RUNX1-positive, and HeH, together with eleven samples of DUX4-rearranged ALL. In addition, the datset contains 9 samples of mononuclear cells, sorted CD34+ (n=3), CD19+ (n=3), and unsorted (n=3), from five normal bone marrow from healthy donors. The dataset is available as raw sequencing reads (fastq; restricted access) or as an annotated multimodal dataset (h5ad). Cells from bone marrow were used for single-cell library preparation, according to the manufacturer’s protocol (10X Genomics CG000208: Chromium Next GEM Single Cell V(D)J Reagent Kits v1.1). The libaries were sequenced on a Novaseq 6000.