Input files for lncRNA-miRNA-mRNA interaction network construction

In this study, we aimed to demonstrate in breast cancer cell lines that anti-cancer drugs with structural similarity may trigger MDR through a similar mechanism. We showed that anti-cancer drugs with structural similarity may contribute to the development of MDR through the same lncRNA-miRNA-mRNA axes. We explained that up-regulation of some lncRNAs sponge and down-regulate miRNAs that have tumor suppressor function, and as a result, SLC & ABC drug-transporter genes that trigger MDR are up-regulated as a mechanism of resistance. In our results, we found interactions that were experimentally shown in breast cancer cell lines in review articles. We present novel lncRNA-miRNA-mRNA axes that have the potential to trigger MDR through multiple SLC & ABC drug transporter genes regulated by multiple miRNAs, which are also regulated by multiple lncRNAs.