Additional file 2 of Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records

Additional file 2: Supplementary Table 1. Read v2 and CTV3 codes used to identify women with vasomotor symptoms. Supplementary Table 2. Numbers of women included in the genome-wide analyses. Supplementary Table 3. Loss-of-function variants in TACR3 identified in analysis of UK Biobank exome sequencing data. Supplementary Table 4. Results of gene burden and single variant analyses of TACR3 in exome sequencing data from UK Biobank. Supplementary Table 5. Comparison of the effects on VMS and age at menarche of rs34867104 (GWAS signal) and rs144292455 (rare loss of function variant) in TACR3. Supplementary Table 6. Conditional analyses of variants in TACR3 associated with VMS and age at menarche. Supplementary Table 7. Genetic signals identified by GWAS of HRT phenotypes. Supplementary Table 8. Results of Mendelian randomisation analyses of association of age at menopause with HRT use. Supplementary Table 9. Heterogeneity in effect of genetic variants on HRT use before and after 2002. Supplementary Table 10. PsychENCODE brain eQTL data for TACR3.