Increased disease burden and resource utilization in patients with hidradenitis suppurativa and concomitant arthritis: a multicenter case-control study

AbstractBackground: The relationship between HS and arthritis is well-established; however, the impact of their combined disease burden and the associated resource consumption have not been determined yet.Objective: To assess disease burden and resource utilization in HS patients with and without arthritis and estimate the prevalence and distribution of arthritis subtypes among HS patients.Methods: A multicenter, retrospective, case-control study of 272 adults (69 with HS and arthritis; 203 with HS only), matched by sex, age, and HS duration. Data were analyzed using non-parametric tests, linear mixed-effects models, and logistic regression.Results: Patients with HS and arthritis had higher rates of immune-mediated diseases, including inflammatory bowel disease (OR 9.44, p<0.0001) and psoriasis (OR 2.99, p=0.0038). They exhibited higher DLQI scores (6.30 vs. 4.03, p=0.031), more dermatology visits (7 vs. 5, p=0.0077), and increased biologic therapy use (72.1% vs. 39.9%, p<0.0001). Arthritis prevalence in HS was 1.7% (0.4-4%) in a cohort of 3,644 patients. Spondyloarthritis was the most common subtype, accounting for 66.6% of cases.Limitations: Retrospective design and tertiary care center bias.Conclusion: HS patients with arthritis have greater disease burden, requiring intensive management and increased healthcare resources highlighting increased healthcare resource consumption and the necessity of interdisciplinary care.We attach Supplementary Tables 1-5 and Figures 1-3 for this study via the following Mendeley link.