Published on 01 January 2010
BindingDB Entry 50031502: Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
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Publication Details
Subfield
Molecular Biology
Field
Biochemistry, Genetics and Molecular Biology
Domain
Life Sciences
Confidence Score
69%
Source
Scholar Data Model
Keywords
Aurora kinase B/Inner centromere protein, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Fibroblast growth factor receptor 1, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Inhibitor of NF-kappa-B kinase (IKK), MAP kinase ERK2, MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 2, PI3-kinase subunit alpha, Platelet-derived growth factor receptor, Protein kinase C alpha type, Rho-associated protein kinase, Ribosomal protein S6 kinase alpha 1, SRC, Serine/threonine-protein kinase mTOR, Tyrosine-protein kinase ABL1, VEGF-receptor 2 and tyrosine-protein kinase SRC, and Vascular endothelial growth factor receptor 2, Wyeth Research, Affinity