Metal−Organic Frameworks as Efficient Oral Detoxifying Agents

Poisoning and accidental oral intoxication are
major health problems worldwide. Considering the insufficient
efficacy of the currently available detoxification treatments, a
pioneering oral detoxifying adsorbent agent based on a single
biocompatible metal−organic framework (MOF) is here
proposed for the efficient decontamination of drugs commonly
implicated in accidental or voluntary poisoning. Furthermore, the
in vivo toxicity and biodistribution of a MOF via oral
administration have been investigated for the first time. Orally
administered upon a salicylate overdose, this MOF is able to
reduce the salicylate gastrointestinal absorption and toxicity more
than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (<9% degradation), poor
intestinal permeation, and safety.