Supporting documents for: Cell painting in activated cells illuminates phenotypic dark space and uncovers novel drug mechanisms of action.

This collection corresponds to an article in Nature Communications with the same title and authors. Source data and scripts used in the analysis are provided here. Raw Histdiff outputs are provided in a separate entry here: 10.5281/zenodo.19501979. There are additional scripts published under two separate DOIs: https://doi.org/10.5281/zenodo.19410518 (https://github.com/LokeyLab/QCGauntlet) and https://doi.org/10.5281/zenodo.19410007 (https://github.com/LokeyLab/HistDiff_standalone). The article was originally made available as a bioRxiv at https://doi.org/10.1101/2025.05.23.655853.