Whole Exome Sequencing VCF Dataset of Control Patients with Structurally Normal Hearts

DescriptionThis repository contains Variant Call Format (VCF) files derived from whole exome sequencing (WES) of control patients with structurally normal hearts.All individuals included in this dataset underwent cardiologic evaluation confirming the absence of congenital structural heart disease. Cardiac normality was established by echocardiographic ultrasonography, ensuring their suitability as controls for comparative genetic studies involving congenital cardiovascular malformations.All patients were evaluated at the Instituto Mexicano del Seguro Social and provided written informed consent for genetic analysis and research use of their data.Sequencing was performed using Illumina whole exome sequencing platforms. This repository includes processed genomic variant files in VCF format only, intended for downstream variant filtering, burden analysis, genotype comparison, and case–control genetic studies.Because these data are derived from clinical patients and are institutional property of the Instituto Mexicano del Seguro Social (IMSS), access is restricted and must be requested directly from the corresponding authors. Data sharing will be granted upon reasonable request and subject to institutional approval.This dataset supports research on genetic susceptibility, rare variant enrichment, comparative exome analysis, and precision medicine approaches in congenital heart disease.Access ConditionsAll patients signed informed consent for participation and genetic analysis.Data access is restricted and must be approved by the corresponding authors.The information is the property of the Instituto Mexicano del Seguro Social (IMSS).No personally identifiable patient information is included in this repository.Data IncludedWhole Exome Sequencing processed variant files (VCF files only)Clinical confirmation of structurally normal heart statusInclusion CriteriaStructurally normal heart confirmed by echocardiographic ultrasonographyNo evidence of congenital heart diseaseAvailability of high-quality whole exome sequencing dataInformed consent for research participationNotesThis repository contains secondary research data intended for scientific collaboration and reproducibility. Due to ethical and institutional restrictions, public download is not available without prior authorization.