Two-/three-dimensional coordination polymers: structural characterization and treatment activity on ulcerative colitis by regulating inflammatory cytokines

In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L₁)_0.5(oba)·DMF]·DMF·H₂O} (1, L₁ = N,N′-bis(4-pyridylmethyl)-naphthalene diimide, H₂oba = 4,4′-oxydibenzoic acid) and [Co(L₂)_0.5(OBA)]_n (2, L₂ = 1,6-bis(benzimidazolyl)hexane) have been successfully synthesized by the solvothermal reaction of H₂oba with different flexible N-donor organic ligands in the presence of Co(NO₃)₂·6H₂O as the metal source. In addition, the biological functional evaluation of the complexes was performed on the ulcerative colitis (UC) model. First, the enzyme-linked immunosorbent assay detection kit was performed to measure the content of the pro-inflammatory cytokines and anti-inflammatory cytokines after complexes treatment. Next, the UC mice model was constructed and the body weight of the mice was measured and recorded at the 7th and 14th day after complexes treatment at the concentration of 5 mg/kg.